Sleep and circadian variability in people with delayed sleep-wake phase disorder versus healthy controls.
Sleep and circadian variability in people with delayed sleep-wake phase disorder versus healthy controls.
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DOI：
10.1016/j.sleep.2017.02.019
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发表时间：
2017-06
期刊：
影响因子：
4.8
通讯作者：
Fogg LF
中科院分区：
文献类型：
--
作者：
Burgess HJ;Park M;Wyatt JK;Rizvydeen M;Fogg LF
目的是比较患有睡眠时相延迟障碍（DSWPD）的成年人与健康对照组在睡眠和昼夜节律变异性方面的差异。
40名参与者（22名DSWPD患者，18名健康对照者）完成了一项为期10天的实验方案，包括连续两个晚上进行暗光褪黑素起始（DLMO）评估，5天的研究间歇期，随后再进行两次DLMO评估。所有参与者均被要求在研究间歇期的最后4天内，按照自己报告的平均睡眠时间安排，在1小时内入睡。我们分析了这4天内参与者的腕部活动记录仪数据，以研究睡眠定时、时长和效率的个体内变异性。我们还研究了研究间歇期前后DLMO的变化。
在相同条件下，DSWPD患者的起床时间和总睡眠时间变异性显著高于健康对照组（p≤0.015）。两组在入睡时间和睡眠效率的个体内变异性方面相似（p≥0.30）。在整个研究间歇期，DLMO相对稳定，只有11%的对照组和27%的DSWPD患者出现DLMO超过1小时的变化。仅在DSWPD样本中，更大的睡眠变异性与DLMO更大的变化相关（r = 0.46，p = 0.03）。这些结果表明，与健康对照组相比，DSWPD患者的睡眠个体内变异性可能更高，这可能会影响DLMO的变异性。睡眠个体内变异性较高的DSWPD患者更有可能出现DLMO变化，这可能会影响睡眠症状以及DSWPD光照和/或褪黑素治疗的最佳时机。
To compare sleep and circadian variability in adults with delayed sleep-wake phase disorder (DSWPD) to healthy controls. Forty participants (22 DSWPD, 18 healthy controls) completed a 10-day protocol, consisting of DLMO assessments on two consecutive nights, a five-day study break, followed by two more DLMO assessments. All participants were instructed to sleep within one hour of their self-reported average sleep schedule for the last four days of the study break. We analyzed the participants’ wrist actigraphy data during these four days to examine intraindividual variability in sleep timing, duration and efficiency. We also examined shifts in the DLMO from before and after the study break. Under the same conditions, people with DSWPD had significantly more variable wake times and total sleep time than healthy controls (p≤0.015). Intraindividual variability in sleep onset time and sleep efficiency was similar between the two groups (p≥0.30). The DLMO was relatively stable across the study break, with only 11% of controls but 27% of DSWPDs showed more than a one hour shift in the DLMO. Only in the DSWPD sample was greater sleep variability associated with a larger shift in the DLMO (r=0.46, p=0.03). These results suggest that intraindividual variability in sleep can be higher in DSWPD versus healthy controls, and this may impact variability in the DLMO. DSWPD patients with higher intraindividual variability in sleep are more likely to have a shifting DLMO, which could impact sleep symptoms and the optimal timing of light and/or melatonin treatment for DSWPD.
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