Individual differences in the amount and timing of salivary melatonin secretion.
Individual differences in the amount and timing of salivary melatonin secretion.
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唾液褪黑激素分泌的数量和时机的个体差异。
DOI：
10.1371/journal.pone.0003055
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发表时间：
2008-08-26
期刊：
影响因子：
3.7
通讯作者：
Fogg, Louis F.
中科院分区：
文献类型：
--
作者：
Burgess, Helen J.;Fogg, Louis F.
本研究的目的是研究个体差异的大样本的完整的褪黑激素配置文件不受光抑制，并寻找褪黑激素分泌的数量和时间和众多的生活方式变量之间可能的关联。褪黑激素分布来自于在昏暗的灯光下每30分钟收集的唾液样本，来自85名健康女性和85名健康男性，年龄在18-45岁之间。褪黑激素的分泌量存在较大的个体差异，峰值范围为2至84 pg/ml。褪黑激素分泌的开始时间范围为18：13至00：26小时。使用激素避孕，就业水平降低，固定睡眠时间表天数减少，白天时间延长和体重减轻与褪黑激素分泌幅度增加有关。使用激素避孕，隐形眼镜，年龄较小，躁狂和偏执的评分较低与褪黑激素分泌的持续时间较长有关。褪黑激素分泌的早期发生与较早的觉醒时间、更多的晨起和没有床伴有关。生活方式和行为变量只能解释褪黑激素分泌量约15%的个体差异，这可能是因为遗传对褪黑激素分泌水平有很大影响。
The aim of this study was to examine individual differences in a large sample of complete melatonin profiles not suppressed by light and search for possible associations between the amount and timing of melatonin secretion and a multitude of lifestyle variables. The melatonin profiles were derived from saliva samples collected every 30 minutes in dim light from 85 healthy women and 85 healthy men aged 18–45 years. There was a large individual variability in the amount of melatonin secreted with peak values ranging from 2 to 84 pg/ml. The onset of melatonin secretion ranged from 18:13 to 00:26 hours. The use of hormonal birth control, reduced levels of employment, a smaller number of days on a fixed sleep schedule, increased day length and lower weight were associated with an increased amplitude of melatonin secretion. The use of hormonal birth control, contact lenses, a younger age, and lower ratings of mania and paranoia were associated with a longer duration of melatonin secretion. An earlier occurrence of the onset of melatonin secretion was associated with an earlier wake time, more morningness and the absence of a bed partner. Lifestyle and behavioral variables were only able to explain about 15% of the individual variability in the amount of melatonin secretion, which is likely because of a substantial genetic influence on the levels of melatonin secretion.
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影响因子：
4
作者：
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通讯作者：
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