Stem cells as potential therapeutics for hearing loss.
Stem cells as potential therapeutics for hearing loss.
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DOI：
10.3389/fnins.2023.1259889
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发表时间：
2023
影响因子：
4.3
通讯作者：
Yang, Jianming
中科院分区：
文献类型：
--
作者：
Fang, Qiaojun;Wei, Yongjie;Zhang, Yuhua;Cao, Wei;Yan, Lin;Kong, Mengdie;Zhu, Yongjun;Xu, Yan;Guo, Lingna;Zhang, Lei;Wang, Weiqing;Yu, Yafeng;Sun, Jingwu;Yang, Jianming
听力障碍是一个全球性的健康问题。干细胞疗法已成为组织再生的前沿方法。在这篇综述中，讨论了干细胞治疗听力损失的最新进展。纳米材料可以调节干细胞微环境，进一步增强治疗效果。纳米材料与干细胞相结合修复和再生受损内耳毛细胞（HC）和螺旋神经节神经元（SGN）的潜力也得到了讨论。干细胞来源的外泌体有助于受损组织的修复和再生，并总结了基于外泌体的听力损失治疗的研究进展。尽管干细胞疗法存在技术和实践限制，但迄今为止报告的研究结果是有希望的，并值得进一步研究以实现最终的临床转化。
Hearing impairment is a global health problem. Stem cell therapy has become a cutting-edge approach to tissue regeneration. In this review, the recent advances in stem cell therapy for hearing loss have been discussed. Nanomaterials can modulate the stem cell microenvironment to augment the therapeutic effects further. The potential of combining nanomaterials with stem cells for repairing and regenerating damaged inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) has also been discussed. Stem cell-derived exosomes can contribute to the repair and regeneration of damaged tissue, and the research progress on exosome-based hearing loss treatment has been summarized as well. Despite stem cell therapy’s technical and practical limitations, the findings reported so far are promising and warrant further investigation for eventual clinical translation.
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