Exposure to polyfluoroalkyl chemicals during pregnancy is not associated with offspring age at menarche in a contemporary British cohort.
Exposure to polyfluoroalkyl chemicals during pregnancy is not associated with offspring age at menarche in a contemporary British cohort.
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DOI：
10.1016/j.envint.2010.08.007
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发表时间：
2011-01
影响因子：
11.8
通讯作者：
Marcus M
中科院分区：
文献类型：
--
作者：
Christensen KY;Maisonet M;Rubin C;Holmes A;Calafat AM;Kato K;Flanders WD;Heron J;McGeehin MA;Marcus M
多氟烷基化学品（PFC）是用于消费品的商业合成化学品。接触某些全氟化学品的情况很普遍，有些全氟化学品可能是内分泌干扰物。我们使用来自英国雅芳父母和儿童纵向研究（ALSPAC）的数据进行巢式病例对照研究，研究初潮年龄与妊娠期间暴露于PFCs之间的关系。病例选自ALSPAC中报告在11.5岁之前初潮的女性后代（n=218），对照组为剩余女孩的随机样本（n=230）。采用在线固相萃取-同位素稀释-高效液相色谱-串联质谱法对1991-1992年孕妇血清中8种全氟碳化物进行了分析。Logistic回归分析用于确定母体血清PFC浓度与初潮年龄提前的几率之间的关系。全氟辛烷磺酸和全氟辛酸是主要的全氟辛烷磺酸（血清浓度中位数分别为19.8纳克/毫升和3.7纳克/毫升）。除一种PFC外，在大多数样品中均可检测到。总PFC浓度因出生次数（与出生顺序负相关; p值<0.0001）和儿童种族（白人较高; p值=0.03）而异。羧酸盐的血清浓度与初潮年龄提前的几率增加有关;全氟辛烷磺酰胺、磺酰胺酯和磺酸盐的浓度都与初潮年龄提前的几率降低有关。然而，所有置信区间均包括空值1.0。ALSPAC研究参与者几乎普遍暴露于大多数PFC检查，但PFC暴露似乎并没有改变他们的后代的初潮年龄。
Polyfluoroalkyl chemicals (PFCs) are commercially synthesized chemicals used in consumer products. Exposure to certain PFCs is widespread, and some PFCs may act as endocrine disruptors. We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) in the United Kingdom to conduct a nested case-control study examining the association between age at menarche, and exposure to PFCs during pregnancy. Cases were selected from female offspring in the ALSPAC who reported menarche before the age of 11.5 years (n=218), and controls were a random sample of remaining girls (n=230). Serum samples taken from the girls’ mothers during pregnancy (1991–1992) were analyzed using on-line solid-phase extraction coupled to isotope dilution high-performance liquid chromatography-tandem mass spectrometry for 8 PFCs. Logistic regression was used to determine association between maternal serum PFC concentrations, and odds of earlier age at menarche. PFOS and PFOA were the predominant PFCs (median serum concentrations of 19.8 ng/mL and 3.7 ng/mL). All but one PFC were detectable in most samples. Total PFC concentration varied by number of births (inverse association with birth order; p-value <0.0001) and race of the child (higher among whites; p-value=0.03). The serum concentrations of carboxylates were associated with increased odds of earlier age at menarche; concentrations of perfluorooctane sulfonamide, the sulfonamide esters and sulfonates were all associated with decreased odds of earlier age at menarche. However, all confidence intervals included the null value of 1.0. ALSPAC study participants had nearly ubiquitous exposure to most PFCs examined, but PFC exposure did not appear to be associated with altered age at menarche of their offspring.
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影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
3.8
作者：
BOOKSTAFF, RC;MOORE, RW;PETERSON, RE
通讯作者：
PETERSON, RE
影响因子：
7.4
作者：
Kuklenyik, Z;Needham, LL;Calafat, AM
通讯作者：
Calafat, AM
DOI：
10.1006/faat.1996.0047
发表时间：
1996-03-01
期刊：
FUNDAMENTAL AND APPLIED TOXICOLOGY
影响因子：
--
作者：
Liu, RCM;Hahn, C;Hurtt, ME
通讯作者：
Hurtt, ME
影响因子：
5.1
作者：
Biro, FM;Huang, B;Daniels, S
通讯作者：
Daniels, S