Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment.
Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment.
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DOI：
10.1016/j.semcancer.2022.03.004
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发表时间：
2022-11
影响因子：
14.5
通讯作者：
Mythreye, Karthikeyan
中科院分区：
文献类型：
--
作者：
Monavarian, Mehri;Elhaw, Amal Taher;Tang, Priscilla W.;Javed, Zaineb;Shonibare, Zainab;Scalise, Carly Bess;Arend, Rebecca;Jolly, Mohit Kumar;Sewell-Loftin, Mary Kathryn;Hempel, Nadine;Mythreye, Karthikeyan
卵巢癌的腹水生态系统由复杂的细胞类型组成，并沐浴在一个富含细胞因子、趋化因子和生长因子的环境中，这些因子直接或间接地影响癌细胞和肿瘤相关细胞的代谢。这种恶性腹水的环境为疾病的蓬勃发展提供了“丰富”的环境，促成了晚期卵巢癌的方方面面，这是一种毁灭性的妇科癌症，在靶向治疗方面存在显著差距。从这个角度出发，我们将重点讨论液体恶性肿瘤微环境中的“非细胞”成分，以及它们如何影响代谢途径。生长因子、趋化因子和细胞因子是已知的代谢调节剂，已被证明影响肿瘤的营养摄取和代谢灵活性，但很少有研究探讨它们在卵巢癌患者恶性腹水中的丰富如何影响腹水驻留细胞的代谢需求。我们在这里重点介绍转化生长因子-β、血管内皮生长因子和白介素3，它们在卵巢癌腹水中经常升高，并且都被描述为对代谢有直接或间接影响，通常是通过代谢酶的基因调节。我们总结已知的知识，描述知识的差距，并提供其他肿瘤类型的例子，以推断卵巢癌潜在的未探索的作用和机制。无细胞腹水成分在患者之间的分布和变化既是一个挑战，也是进一步了解腹水如何导致疾病异质性的机会。该综述还强调了腹水衍生因子在调节腹水代谢环境方面的研究机会，这可能是未来帮助临床决策的独特标志。
The ascites ecosystem in ovarian cancer is inhabited by complex cell types and is bathed in an environment rich in cytokines, chemokines, and growth factors that directly and indirectly impact metabolism of cancer cells and tumor associated cells. This milieu of malignant ascites, provides a ‘rich’ environment for the disease to thrive, contributing to every aspect of advanced ovarian cancer, a devastating gynecological cancer with a significant gap in targeted therapeutics. In this perspective we focus our discussions on the ‘acellular’ constituents of this liquid malignant tumor microenvironment, and how they influence metabolic pathways. Growth factors, chemokines and cytokines are known modulators of metabolism and have been shown to impact nutrient uptake and metabolic flexibility of tumors, yet few studies have explored how their enrichment in malignant ascites of ovarian cancer patients contributes to the metabolic requirements of ascites-resident cells. We focus here on TGF-βs, VEGF and ILs, which are frequently elevated in ovarian cancer ascites and have all been described to have direct or indirect effects on metabolism, often through gene regulation of metabolic enzymes. We summarize what is known, describe gaps in knowledge, and provide examples from other tumor types to infer potential unexplored roles and mechanisms for ovarian cancer. The distribution and variation in acellular ascites components between patients poses both a challenge and opportunity to further understand how the ascites may contribute to disease heterogeneity. The review also highlights opportunities for studies on ascites-derived factors in regulating the ascites metabolic environment that could act as a unique signature in aiding clinical decisions in the future.
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影响因子：
4.6
作者：
Buas MF;Drescher CW;Urban N;Li CI;Bettcher L;Hait NC;Moysich KB;Odunsi K;Raftery D;Yan L
通讯作者：
Yan L
影响因子：
4.6
作者：
Dar S;Chhina J;Mert I;Chitale D;Buekers T;Kaur H;Giri S;Munkarah A;Rattan R
通讯作者：
Rattan R
影响因子：
5
作者：
Dalal, Venus;Kumar, Raman;Vanamail, Perumal
通讯作者：
Vanamail, Perumal
影响因子：
3.7
作者：
Anderson AS;Roberts PC;Frisard MI;Hulver MW;Schmelz EM
通讯作者：
Schmelz EM
影响因子：
64.5
作者：
De Bock, Katrien;Georgiadou, Maria;Carmeliet, Peter
通讯作者：
Carmeliet, Peter