Multi-omics for biomarker approaches in the diagnostic evaluation and management of abdominal pain and irritable bowel syndrome: what lies ahead.
Multi-omics for biomarker approaches in the diagnostic evaluation and management of abdominal pain and irritable bowel syndrome: what lies ahead.
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用于诊断和管理腹痛和肠易激综合征的生物标志物方法的多媒体方法：未来。
DOI：
10.1080/19490976.2023.2195792
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发表时间：
2023-01
期刊：
影响因子：
12.2
通讯作者：
中科院分区：
文献类型：
--
作者：
以腹痛为特征的肠-脑相互作用的常见疾病（包括肠易激综合征（IBS））的可靠生物标志物是迫切需要的，以加强护理和开发个体化治疗。内脏高敏感性的病理生理机制的动态和异质性挑战了成功的生物标志物的开发。因此，缺乏有效的治疗IBS疼痛的方法。然而，现代组学技术的最新进展为获得对疼痛和伤害感受机制的深刻生物学见解提供了新的机会。用于互补组学方法的大规模数据整合的新方法进一步扩展了我们对复杂生物网络及其对腹痛的共同贡献的整体理解的能力。在这里，我们回顾内脏高敏感性的机制，重点是IBS。我们讨论了通过单组学研究确定的IBS疼痛候选生物标志物，并总结了新兴的多组学方法，用于开发新的生物标志物，这些生物标志物可能会改变IBS和腹痛患者的临床护理。
Reliable biomarkers for common disorders of gut–brain interaction characterized by abdominal pain, including irritable bowel syndrome (IBS), are critically needed to enhance care and develop individualized therapies. The dynamic and heterogeneous nature of the pathophysiological mechanisms that underlie visceral hypersensitivity have challenged successful biomarker development. Consequently, effective therapies for pain in IBS are lacking. However, recent advances in modern omics technologies offer new opportunities to acquire deep biological insights into mechanisms of pain and nociception. Newer methods for large-scale data integration of complementary omics approaches have further expanded our ability to build a holistic understanding of complex biological networks and their co-contributions to abdominal pain. Here, we review the mechanisms of visceral hypersensitivity, focusing on IBS. We discuss candidate biomarkers for pain in IBS identified through single omics studies and summarize emerging multi-omics approaches for developing novel biomarkers that may transform clinical care for patients with IBS and abdominal pain.
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影响因子：
29.4
作者：
Cenac, Nicolas;Bautzova, Tereza;Vergnolle, Nathalie
通讯作者：
Vergnolle, Nathalie
影响因子：
6
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5.2
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Sinha R
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11
作者：
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通讯作者：
Mayer, Emeran A.
影响因子：
3.3
作者：
Bhatt, Ravi R.;Gupta, Arpana;Tillisch, Kirsten
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Tillisch, Kirsten