Polyclonal Treg cells modulate T effector cell trafficking.
Polyclonal Treg cells modulate T effector cell trafficking.
复制标题
DOI：
10.1002/eji.201141503
复制
发表时间：
2011-10
影响因子：
5.4
通讯作者：
Shevach, Ethan M.
中科院分区：
文献类型：
--
作者：
Davidson, Todd S.;Shevach, Ethan M.
在这项研究中，我们已经分析了多克隆Foxp 3 + T细胞，效应T（Teff）细胞和DC之间的相互作用的体内动力学，以进一步了解Treg介导的抑制机制。将多克隆活化的TcR共转移到正常小鼠中可减弱EAE的诱导。疾病的抑制与脊髓中Teff细胞数量的减少密切相关，但与Treg介导的Th 1/Th 17分化抑制无关。共转移TcR与TCR Tg Teff细胞，然后通过多种途径免疫接种，导致引流免疫部位的淋巴结中Teff细胞数量增加，而不抑制Teff细胞分化。在Teff存在下，在血液中可以检测到较少的Teff细胞，并且在改良的迟发型超敏反应测定中，较少的T细胞可以到达抗原暴露部位。Teff细胞从LN中回收的Teff细胞表达CXCR 4、多配体蛋白聚糖和磷酸鞘氨醇受体S1 P1的水平降低。因此，多克隆Teff通过靶向运输途径影响Teff细胞应答，从而允许免疫在淋巴器官中发展，但限制允许进入组织的潜在自身攻击性细胞的数量。
In this study, we have analyzed the in vivo dynamics of the interaction between polyclonal Foxp3+ Tregs, effector T (Teff) cells, and DCs in order to further our understanding of the mechanisms of Treg-mediated suppression. Co-transfer of polyclonal activated Tregs into normal mice attenuated the induction of EAE. Suppression of disease strongly correlated with a reduced number of Teff cells in the spinal cord, but not with Treg-mediated inhibition of Th1/Th17 differentiation. Co-transfer of Tregs with TCR Tg Teff cells followed by immunization by multiple routes resulted in an enhanced number of Teff cells in the lymph nodes draining the site of immunization without an inhibition of Teff cell differentiation. Fewer Teff cells could be detected in the blood in the presence of Tregs and fewer T cells could access a site of antigen exposure in a modified delayed type hypersensitivity assay. Teff cells recovered from LN in the presence of Tregs expressed decreased levels of CXCR4, syndecan, and the sphingosine phosphate receptor, S1P1. Thus, polyclonal Tregs influence Teff cell responses by targeting trafficking pathways, thus allowing immunity to develop in lymphoid organs, but limiting the number of potentially auto-aggressive cells that are allowed to enter the tissues.
登录
查看更多内容
影响因子：
30.5
作者：
通讯作者：
--
DOI：
10.4049/jimmunol.1000423
发表时间：
2010-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fulton RB;Meyerholz DK;Varga SM
通讯作者：
Varga SM
影响因子：
5.4
作者：
Huter, Eva N.;Punkosdy, George A.;Glass, Deborah D.;Cheng, Lily I.;Ward, Jerrold M.;Shevach, Ethan M.
通讯作者：
Shevach, Ethan M.
影响因子：
4.4
作者：
DiPaolo, Richard J.;Brinster, Carine;Shevach, Ethan M.
通讯作者：
Shevach, Ethan M.
影响因子：
32.4
作者：
Boissonnas, Alexandre;Scholer-Dahirel, Alix;Amigorena, Sebastian
通讯作者：
Amigorena, Sebastian