Dynamic causal modeling reveals increased cerebellar- periaqueductal gray communication during fear extinction.
Dynamic causal modeling reveals increased cerebellar- periaqueductal gray communication during fear extinction.
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DOI：
10.3389/fnsys.2023.1148604
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发表时间：
2023
影响因子：
3
通讯作者：
Moran, Rosalyn J.
中科院分区：
文献类型：
--
作者：
Paci, Elena;Lumb, Bridget M.;Apps, Richard;Lawrenson, Charlotte L.;Moran, Rosalyn J.
恐惧记忆的消失是调节防御行为的重要组成部分，有助于适应生存所必需的过程。小脑内侧核(MCN)与腹外侧导水管周围灰质(VlPAG)有双向联系，参与调节恐惧的多个方面，如条件性恐惧学习和防御性运动输出的表达。然而，尚不清楚在条件性恐惧消退过程中，MCN和vlPAG之间的通讯如何变化。我们使用动态因果模型(DCMS)来推断大鼠听觉线索条件性恐惧提取和消退过程中MCN和vlPAG之间的有效连接。DCMS通过使用神经生物学激励的模型来重现由脑区内和脑区之间的突触连接产生的突触后电位的动态，来确定神经元来源之间的因果关系。同时从MCN和vlPAG记录条件性音调偏移期间的听觉事件相关电位(ERPs)，然后对其进行建模，以确定这些脑区之间突触输入强度的变化，以及在消退试验中与冻结行为的关系。DCMS的结构被构建成诱发反应的模型，以最好地代表条件性音调偏移ERPs，并适用于代表PAG和小脑回路。利用参数经验贝叶斯(PEB)分析，我们发现，通过增强突触效应从MCN到vlPAG的信息流的强度与灭绝期间的冻结成反比，即从MCN到vlPAG的通信随着灭绝的增加而增加。这一结果与小脑参与预测恐惧消退的过程是一致的。
The extinction of fear memories is an important component in regulating defensive behaviors, contributing toward adaptive processes essential for survival. The cerebellar medial nucleus (MCN) has bidirectional connections with the ventrolateral periaqueductal gray (vlPAG) and is implicated in the regulation of multiple aspects of fear, such as conditioned fear learning and the expression of defensive motor outputs. However, it is unclear how communication between the MCN and vlPAG changes during conditioned fear extinction. We use dynamic causal models (DCMs) to infer effective connectivity between the MCN and vlPAG during auditory cue-conditioned fear retrieval and extinction in the rat. DCMs determine causal relationships between neuronal sources by using neurobiologically motivated models to reproduce the dynamics of post-synaptic potentials generated by synaptic connections within and between brain regions. Auditory event related potentials (ERPs) during the conditioned tone offset were recorded simultaneously from MCN and vlPAG and then modeled to identify changes in the strength of the synaptic inputs between these brain areas and the relationship to freezing behavior across extinction trials. The DCMs were structured to model evoked responses to best represent conditioned tone offset ERPs and were adapted to represent PAG and cerebellar circuitry. With the use of Parametric Empirical Bayesian (PEB) analysis we found that the strength of the information flow, mediated through enhanced synaptic efficacy from MCN to vlPAG was inversely related to freezing during extinction, i.e., communication from MCN to vlPAG increased with extinction. The results are consistent with the cerebellum contributing to predictive processes that underpin fear extinction.
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影响因子：
10.5
作者：
BLACKWOOD, DHR;MUIR, WJ
通讯作者：
MUIR, WJ
影响因子：
7.7
作者：
Lawrenson C;Paci E;Pickford J;Drake RAR;Lumb BM;Apps R
通讯作者：
Apps R
DOI：
10.1073/pnas.160266497
发表时间：
2000-08-01
影响因子：
11.1
作者：
Ploghaus, A;Tracey, I;Matthews, PM
通讯作者：
Matthews, PM
影响因子：
25
作者：
Groessl F;Munsch T;Meis S;Griessner J;Kaczanowska J;Pliota P;Kargl D;Badurek S;Kraitsy K;Rassoulpour A;Zuber J;Lessmann V;Haubensak W
通讯作者：
Haubensak W
影响因子：
25
作者：
Johansen, Joshua P.;Tarpley, Jason W.;LeDoux, Joseph E.;Blair, Hugh T.
通讯作者：
Blair, Hugh T.