Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment.
Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment.
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DOI：
10.3892/ijo.2012.1335
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发表时间：
2012-04
影响因子：
5.2
通讯作者：
Wang TT
中科院分区：
文献类型：
--
作者：
Hudson TS;Perkins SN;Hursting SD;Young HA;Kim YS;Wang TC;Wang TT
Phenethyl isothiocyanate (PEITC) is a candidate anticancer compound found in certain cruciferous vegetables. In our tumor cell xenograft model, dietary administration of PEITC (100–150 mg/kg body weight/d) inhibited androgen-responsive LNCaP human prostate cancer cell tumor growth. We found that dietary treatment with PEITC significantly inhibited tumor platelet/endothelial cell adhesion molecule (PECAM-1/CD31) expression, a marker of angiogenesis. By contrast, we did not find the inhibitory effects of PEITC on tumor growth to be associated with alteration of specific markers for apoptosis, cell proliferation or androgen receptor-mediated pathways. Consistent with in vivo results, PEITC exerted little effects on cell proliferation, cell cycle and androgen-dependent pathways. Interestingly, PEITC significantly attenuated LNCaP cell plating efficiency that correlated with inhibition of integrin family proteins integrin β1, α2 and α6 mRNA expression. Thus, PEITC may be a dietary factor that inhibits androgen-responsive prostate tumor growth indirectly by selectively targeting factors involved in the tumor microenvironment.
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影响因子：
5.5
作者：
Cao, GY;O'Brien, CD;DeLisser, HM
通讯作者：
DeLisser, HM
影响因子：
4.6
作者：
Takahashi, Yoko;Lavigne, Jackie A.;Wang, Thomas T. Y.
通讯作者：
Wang, Thomas T. Y.
影响因子：
5.6
作者：
Sroka IC;Anderson TA;McDaniel KM;Nagle RB;Gretzer MB;Cress AE
通讯作者：
Cress AE
DOI：
10.1093/jnci/87.5.354
发表时间：
1995-03-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
WHITTEMORE, AS;LELE, C;ORENTREICH, N
通讯作者：
ORENTREICH, N
影响因子：
5.1
作者：
SCHUMAN, LM;MANDEL, JS
通讯作者：
MANDEL, JS