Expression of the neuroglandular antigen and analogues in melanoma. CD9 expression appears inversely related to metastatic potential of melanoma
Expression of the neuroglandular antigen and analogues in melanoma. CD9 expression appears inversely related to metastatic potential of melanoma
复制标题
神经腺抗原和类似物在黑色素瘤中的表达。
DOI：
--
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发表时间：
1993
影响因子：
6.4
通讯作者：
P. Hersey
中科院分区：
文献类型：
--
作者：
Z. Si;P. Hersey
用免疫组织化学方法检测黑色素瘤转移潜能与神经腺抗原(CD63)及其家族成员CD53、CD37、CD9和抗增殖抗体靶标(TapA-1)以及MHC-I、II类抗原的表达之间的关系。用来确定转移潜力的标准是它们与原发黑色素瘤厚度的关系，以及原发黑色素瘤垂直和径向生长阶段以及原发和转移性黑色素瘤之间表达的差异。研究还包括基底细胞癌(BCC)和鳞状细胞癌(SCC)作为低转移潜能的恶性皮肤癌的对照。CD9和MHC-1类抗原的表达与原发灶厚度呈负相关，CD9主要在原发灶表达，而在转移瘤中表达较少。CD9和MHC-Class-1在黑色素瘤中的表达呈正相关，在低转移潜能的基底细胞癌和鳞状细胞癌中均有表达，而在复合痣中无表达。CD63和TAPA-1在痣上表达，而在鳞癌和基底细胞癌上不表达。Leu13是一种与淋巴瘤中TAPA-1相关的分子，在34例原发黑色素瘤和21例转移性黑色素瘤中分别有5例和5例表达。CD53和CD37在黑色素瘤中均未检测到。我们的结果表明，在黑色素瘤中表达了神经腺抗原的几个成员，CD9在原发黑色素瘤中的低表达可能对转移的可能性有预后意义。
Immunohistological methods were used to examine the relation between the metastatic potential of melanoma and expression of the neuroglandular antigen (CD63) and other members of this family of molecules, CD53, CD37, CD9 and the target of an anti‐proliferative antibody (TAPA‐1), as well as MHC‐class‐I and ‐II antigens. The criteria used to establish metastatic potential were their relation to thickness of the primary melanoma, and differences in expression between vertical and radial growth phases of primary melanoma and between primary and metastatic melanoma. Studies on basal‐cell carcinoma (BCC) and squamous‐cell carcinoma (SCC) were also included as controls for malignant skin cancers with low metastatic potential. Expression of CD9 and MHC‐class‐1 antigen was found to be inversely related to thickness of the primary tumor, and CD9 was expressed predominantly on primary rather than on metastatic tumors. CD9 expression correlated with MHC‐class‐1 expression on melanoma, and both were expressed on BCCs and SCCs having low metastatic potential, but not on compound nevi. CD63 and TAPA‐1 were expressed on nevi but not on SCC and BCC. Leu 13 is a molecule associated with TAPA‐1 in lymphomas, and was found to be expressed in sections from 5 out of 34 primary and 5 out of 21 metastatic melanoma. CD53 and CD37 were not detected on melanoma. Our results indicate that several members of the neuroglandular antigen are expressed in melanoma and that low expression of CD9 on primary melanomas might have prognostic significance with respect to the potential for metastasis.
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影响因子：
11.2
作者：
S. Albelda;S. Mette;D. Elder;R. Stewart;L. Damjanovich;M. Herlyn;C. Buck
通讯作者：
S. Albelda;S. Mette;D. Elder;R. Stewart;L. Damjanovich;M. Herlyn;C. Buck
与黑色素瘤肿瘤进展早期相关的抗原的分子克隆和表征。
影响因子：
11.2
作者：
Hotta,H;Ross,AH;Huebner,K;Isobe,M;Wendeborn,S;Chao,MV;Ricciardi,RP;Tsujimoto,Y;Croce,CM;Koprowski,H
通讯作者：
Koprowski,H
通过针对 16kd 人类白细胞表面抗原的抗体诱导 T 细胞聚集。
DOI：
--
发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chen,YX;Welte,K;Gebhard,DH;Evans,RL
通讯作者：
Evans,RL
影响因子：
--
作者：
ATKINSON, B;ERNST, CS;KOPROWSKI, H
通讯作者：
KOPROWSKI, H
黑色素瘤患者局部转移灶中 HLA 抗原的水平和疾病的临床病程。
影响因子：
11.2
作者：
vanDuinen,SG;Ruiter,DJ;Broecker,EB;vanderVelde,EA;Sorg,C;Welvaart,K;Ferrone,S
通讯作者：
Ferrone,S