The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease.
The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease.
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DOI：
10.1016/j.semnephrol.2018.01.003
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发表时间：
2018-03
影响因子：
3.3
通讯作者：
Susztak K
中科院分区：
文献类型：
--
作者：
Li SY;Susztak K
过氧化物酶体增殖物激活受体γ辅活化子1α(PGC-1α)是线粒体生物发生和功能的关键转录调控因子。最近的几项研究评估了前列腺素C-1α在健康和疾病条件下不同类型的肾脏细胞中的作用。肾小管细胞主要依靠线粒体脂肪酸氧化(FAO)来产生能量。在急性和慢性肾脏疾病的患者样本和小鼠模型中，通常可以观察到PGC-1α表达和粮农组织的减少。相反，增加肾小管细胞中PGC-1α的表达可以恢复能量不足，并已被证明对急性和慢性肾脏疾病具有保护作用。其他肾脏细胞，如足细胞和内皮细胞，代谢活性较低，对pGC-1α的耐受性较窄。足细胞中PGC-1α水平升高可诱导足细胞增殖和肾小球病变的发生，而内皮细胞中PGC-1α水平升高则改变内皮功能，导致微血管病变，从而突出PGC-1α在肾脏中的细胞类型特异性作用。
Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) is a key transcriptional regulator of mitochondrial biogenesis and function. Several recent studies evaluated the role of PGC-1α in various renal cell types in healthy and disease conditions. Renal-tubule cells mostly depend on mitochondrial fatty acid oxidation (FAO) for energy generation. A decrease in PGC-1α expression and FAO is commonly observed in patient samples and mouse models with acute and chronic kidney disease. Conversely, increasing PGC-1α expression in renal-tubule cells restores energy deficit and has been shown to protect from acute and chronic kidney disease. Other kidney cells, such as podocytes and endothelial cells, are less metabolically active and have a narrow PGC-1α tolerance. Increasing PGC-1α levels in podocytes induces podocyte proliferation and collapsing glomerulopathy development, while increasing PGC1-α in endothelial cells alters endothelial function and causes microangiopathy, thus highlighting the cell-type-specific role of PGC-1α in the kidney.
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影响因子：
29
作者：
Sawada N;Jiang A;Takizawa F;Safdar A;Manika A;Tesmenitsky Y;Kang KT;Bischoff J;Kalwa H;Sartoretto JL;Kamei Y;Benjamin LE;Watada H;Ogawa Y;Higashikuni Y;Kessinger CW;Jaffer FA;Michel T;Sata M;Croce K;Tanaka R;Arany Z
通讯作者：
Arany Z
影响因子：
4.6
作者：
Ozawa S;Ueda S;Imamura H;Mori K;Asanuma K;Yanagita M;Nakagawa T
通讯作者：
Nakagawa T
DOI：
10.1073/pnas.0603615103
发表时间：
2006-06-27
影响因子：
11.1
作者：
Arany, Zoltan;Novikov, Mikhail;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.
影响因子：
5.5
作者：
Abe, Yoshifusa;Sakairi, Toru;Kopp, Jeffrey B.
通讯作者：
Kopp, Jeffrey B.
影响因子：
7.1
作者：
Fernandez-Marcos, Pablo J.;Auwerx, Johan
通讯作者：
Auwerx, Johan