Immunoreactive corticotropin-releasing factor in human plasma.
Immunoreactive corticotropin-releasing factor in human plasma.
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人血浆中的免疫反应性促肾上腺皮质激素释放因子。
DOI：
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发表时间：
1985
影响因子：
15.9
通讯作者：
K. Shizume
中科院分区：
文献类型：
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作者：
T. Suda;N. Tomori;F. Yajima;T. Sumitomo;Y. Nakagami;T. Ushiyama;H. Demura;K. Shizume
血浆免疫反应性促肾上腺皮质激素释放因子（I-CRF）水平测定通过使用人CRF放射免疫分析和免疫亲和程序。正常受试者的基础血浆I-CRF水平为6 +/- 0.5 pg/ml（平均值+/- SD）。我们发现，大多数血浆I-CRF水平受到压力，负反馈和昼夜节律的影响。基础I-CRF水平在Addison病、纳尔逊综合征、垂体大腺瘤引起的垂体功能减退症和产生CRF和促肾上腺皮质激素的肿瘤患者中较高。在库欣综合征患者、皮质类固醇治疗患者和下丘脑垂体功能减退症患者中检测到非常低但显著的I-CRF量（1-3 pg/ml）。这些结果表明，血浆I-CRF的主要成分是下丘脑起源，但不能排除其他下丘脑外组织作为血浆I-CRF的次要来源。
Plasma immunoreactive corticotropin-releasing factor (I-CRF) levels were determined by using a human CRF radioimmunoassay and an immunoaffinity procedure. The basal plasma I-CRF level in normal subjects was 6 +/- 0.5 pg/ml (mean +/- SD). We found that most plasma I-CRF levels were affected by stress, negative feedback, and circadian rhythm. Basal I-CRF levels were high in patients with Addison's disease, Nelson's syndrome, hypopituitarism stemming from pituitary macroadenoma, and CRF- and adrenocorticotropic hormone-producing tumors. A very low, but significant, amount of I-CRF was detected (1-3 pg/ml) in patients with Cushing's syndrome, in corticosteroid-treated patients, and in a patient with hypothalamic hypopituitarism. These results suggest that a major component of plasma I-CRF is of hypothalamic origin, however, other extrahypothalamic tissues cannot be ruled out as a minor source of plasma I-CRF.
DOI：
10.1073/pnas.80.15.4851
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
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作者：
RIVIER, J;SPIESS, J;VALE, W
通讯作者：
VALE, W