Controlling cytomegalovirus: helping the immune system take the lead.
Controlling cytomegalovirus: helping the immune system take the lead.
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DOI：
10.3390/v6062242
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发表时间：
2014-05-27
期刊：
影响因子：
--
通讯作者：
Bollard CM
中科院分区：
文献类型：
--
作者：
Hanley PJ;Bollard CM
巨细胞病毒属于疱疹病毒科，与人类一起进化了数千年，在潜伏期、免疫逃避和传播之间保持着复杂的平衡。虽然超过 70% 的人类有 CMV 感染的证据，但大多数健康人几乎没有表现出原发感染的临床症状，并且在免疫功能正常的宿主持续感染期间很少观察到 CMV 疾病。尽管大多数感染者没有症状，但从免疫学角度来看，巨细胞病毒通过感染并潜伏在抗原呈递细胞中劫持免疫系统，这些细胞偶尔会亚临床地重新激活并向 T 细胞呈递抗原，最终导致巨细胞病毒特异性 T 细胞膨胀，直到它们能够损害整个 T 细胞库的 10%。由于其对免疫系统的影响及其在干细胞和器官移植等领域的重要性，CMV 与免疫反应之间的关系已得到深入研究。在这里，我们对许多此类研究进行了回顾，并深入了解了 CMV 特异性 T 细胞目前如何用于治疗。
Cytomegalovirus, of the Herpesviridae family, has evolved alongside humans for thousands of years with an intricate balance of latency, immune evasion, and transmission. While upwards of 70% of humans have evidence of CMV infection, the majority of healthy people show little to no clinical symptoms of primary infection and CMV disease is rarely observed during persistent infection in immunocompetent hosts. Despite the fact that the majority of infected individuals are asymptomatic, immunologically, CMV hijacks the immune system by infecting and remaining latent in antigen-presenting cells that occasionally reactivate subclinically and present antigen to T cells, eventually causing the inflation of CMV-specific T cells until they can compromise up to 10% of the entire T cell repertoire. Because of this impact on the immune system, as well as its importance in fields such as stem cell and organ transplant, the relationship between CMV and the immune response has been studied in depth. Here we provide a review of many of these studies and insights into how CMV-specific T cells are currently being used therapeutically.
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影响因子：
30.5
作者：
Andrews, DM;Andoniou, CE;Degli-Esposti, MA
通讯作者：
Degli-Esposti, MA
DOI：
10.1073/pnas.95.7.3937
发表时间：
1998-03-31
影响因子：
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影响因子：
20.3
作者：
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6.4
作者：
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通讯作者：
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