Functional Characterization of Tn 4401 , a Tn 3 -Based Transposon Involved in bla KPC Gene Mobilization (cid:1)
Functional Characterization of Tn 4401 , a Tn 3 -Based Transposon Involved in bla KPC Gene Mobilization (cid:1)
复制标题
Tn 4401（一种参与 bla KPC 基因动员的基于 Tn 3 的转座子）的功能表征 (cid:1)
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
P. Nordmann
中科院分区：
文献类型：
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作者：
G. Cuzon;T. Naas;P. Nordmann
碳青霉烯酶基因bla KPC在世界范围内迅速传播，位于基于Tn 3的转座子Tn 4401上。在转座接合试验中，Tn 4401能够以4.4（cid：1）10（cid：2）6 /受体细胞的频率动员bla KPC-2基因。在每次插入时证明了5-bp靶位点重复，无靶位点特异性。本研究证明Tn 4401是一个能够高频率调动bla KPC基因的活性转座子。
The carbapenemase gene bla KPC , which is rapidly spreading worldwide, is located on a Tn 3 -based trans- poson, Tn 4401 . In a transposition-conjugation assay, Tn 4401 was able to mobilize bla KPC-2 gene at a frequency of 4.4 (cid:1) 10 (cid:2) 6 /recipient cell. A 5-bp target site duplication was evidenced upon each insertion without target site specificity. This study demonstrated that Tn 4401 is an active transposon capable of mobilizing bla KPC genes at high frequency.
Tn5 转座的拷贝数控制。
影响因子：
3.3
作者：
Johnson,RC;Reznikoff,WS
通讯作者：
Reznikoff,WS