Memory Consolidation during Ultra-short Offline States
Memory Consolidation during Ultra-short Offline States
复制标题
超短离线状态期间的内存整合
DOI：
10.1162/jocn_a_02035
复制
发表时间：
2023
影响因子：
3.2
通讯作者：
Collins, Megan
中科院分区：
文献类型：
--
作者：
Wamsley, Erin J.;Arora, Madison;Gibson, Hannah;Powell, Piper;Collins, Megan
传统上，神经科学和心理学研究的是人脑在“在线”关注环境的过程中，参与者积极参与处理感觉刺激的过程。然而，越来越多的证据表明，清醒的大脑也会间歇性地进入“脱机”状态，在此期间，感觉处理受到抑制，我们的注意力向内转移。事实上，人类在醒着的时候可能有多达一半的时间处于离线状态[Wamsley，E.J.和Summer，T.在清醒时自发地进入“离线”状态：记忆巩固的机制？认知神经科学杂志，32,1714-1734,2020；Killingsworth，M.A.，&Gilbert，D.T.走神是一种不愉快的心态。科学，330,932,2010]。在线和离线形式的觉醒之间交替的功能仍不清楚。我们假设，在线和离线状态之间的快速切换使大脑能够在编码新信息和巩固已编码信息的相互竞争的需求之间交替。共有46名参与者(34名女性)在30分钟的保持间隔之前进行了一项记忆任务的训练，在此期间，他们完成了一项简单的注意力任务，同时进行了高密度脑电和斜视测量记录。我们使用数据驱动的方法将此保留间隔解析为一系列离散的在线和离线状态，时间分辨率为5秒。我们发现了三种不同状态的证据，其中一种是离线状态，其特征非常适合支持记忆巩固，包括脑电缓慢振荡功率增加，对外部环境的注意力减少，以及瞳孔直径增加(去甲肾上腺素增加的指标)。在编码后处于脱机状态的参与者在延迟测试中表现出更好的记忆力。这些观察结果与假设一致，即即使是短暂的、几秒钟长的脱机状态也可能支持记忆巩固的早期阶段。
Traditionally, neuroscience and psychology have studied the human brain during periods of “online” attention to the environment, while participants actively engage in processing sensory stimuli. However, emerging evidence shows that the waking brain also intermittently enters an “offline” state, during which sensory processing is inhibited and our attention shifts inward. In fact, humans may spend up to half of their waking hours offline [Wamsley, E. J., & Summer, T. Spontaneous entry into an “offline” state during wakefulness: A mechanism of memory consolidation?Journal of Cognitive Neuroscience,32, 1714–1734, 2020; Killingsworth, M. A., & Gilbert, D. T. A wandering mind is an unhappy mind.Science,330, 932, 2010]. The function of alternating between online and offline forms of wakefulness remains unknown. We hypothesized that rapidly switching between online and offline states enables the brain to alternate between the competing demands of encoding new information and consolidating already-encoded information. A total of 46 participants (34 female) trained on a memory task just before a 30-min retention interval, during which they completed a simple attention task while undergoing simultaneous high-density EEG and pupillometry recording. We used a data-driven method to parse this retention interval into a sequence of discrete online and offline states, with a 5-sec temporal resolution. We found evidence for three distinct states, one of which was an offline state with features well-suited to support memory consolidation, including increased EEG slow oscillation power, reduced attention to the external environment, and increased pupil diameter (a proxy for increased norepinephrine). Participants who spent more time in this offline state following encoding showed improved memory at delayed test. These observations are consistent with the hypothesis that even brief, seconds-long entry into an offline state may support the early stages of memory consolidation.
登录
查看更多内容
DOI：
10.1016/s0079-6123(03)45015-2
发表时间：
2004-01-01
期刊：
ACETYLCHOLINE IN THE CEREBRAL CORTEX
影响因子：
--
作者：
Hasselmo, ME;McGaughy, J
通讯作者：
McGaughy, J
影响因子：
3.2
作者：
Wamsley, Erin J.;Summer, Theodore
通讯作者：
Summer, Theodore
影响因子：
19.9
作者：
Klimesch, Wolfgang
通讯作者：
Klimesch, Wolfgang
睡眠慢振荡和可塑性
影响因子：
5.7
作者：
I. Timofeev;S. Chauvette
通讯作者：
S. Chauvette
持续有意识体验的神经相关性：任务无关性和刺激无关性都与默认网络活动有关。
影响因子：
3.7
作者：
Stawarczyk D;Majerus S;Maquet P;D'Argembeau A
通讯作者：
D'Argembeau A