The Multifaceted Role of Perivascular Macrophages in Tumors.
The Multifaceted Role of Perivascular Macrophages in Tumors.
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DOI:
10.1016/j.ccell.2016.05.017
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发表时间:
2016-07-11
期刊:
影响因子:
50.3
通讯作者:
Pollard JW
中科院分区:
文献类型:
--
作者:
Lewis CE;Harney AS;Pollard JW
Evidence has emerged for macrophages in the perivascular niche of tumors regulating important processes like angiogenesis, various steps in the metastatic cascade, the recruitment and activity of other tumor-promoting leukocytes, and tumor responses to frontline therapies like irradiation and chemotherapy. Understanding the mechanisms controlling the recruitment, retention, and function of these cells could identify important targets for anti-cancer therapeutics.
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