Minocycline affects cocaine sensitization in mice.
Minocycline affects cocaine sensitization in mice.
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DOI：
10.1016/j.neulet.2009.01.078
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发表时间：
2009-03-20
影响因子：
2.5
通讯作者：
Manev H
中科院分区：
文献类型：
--
作者：
Chen H;Uz T;Manev H
越来越多的证据表明四环素类抗生素米诺环素与阿片类药物和安非他明等易滥用药物之间存在相互作用。在这项工作中，我们测试的假设，类似于其对甲基苯丙胺诱导的运动敏化的影响，二甲胺四环素可能会影响可卡因的行为效应。使用自动化系统在雄性C57 BL/6 J小鼠中进行实验以测量自发活动。我们发现，80毫克/公斤米诺环素显着降低自发活动时，单独或注射前30分钟可卡因，增加自发活动。为了研究米诺环素是否选择性地影响由每天四次注射10 mg/kg可卡因诱导的运动致敏的发展，我们寻求本身不影响运动活性的米诺环素给药时间表。因此，我们选择40 mg/kg米诺环素给药前3小时可卡因;米诺环素不影响可卡因刺激的自发活动的第一天，但防止可卡因致敏的发展。我们还测试了米诺环素是否会影响已经建立的可卡因致敏性。在通过每天四次注射建立致敏作用后，停止可卡因治疗，每天（第5-11天）或仅在第11天用米诺环素治疗小鼠。米诺环素治疗对可卡因致敏小鼠在第11天对可卡因激发剂量的反应没有影响。米诺环素干扰可卡因致敏作用的机制还有待进一步研究。
Growing evidence has pointed to an interaction between the tetracycline antibiotic minocycline and drugs with abuse liability such as opioids and amphetamines. In this work, we tested the hypothesis that similar to its effects on methamphetamine-induced locomotor sensitization, minocycline may influence the behavioral effects of cocaine. Experiments were performed in male C57BL/6J mice using an automated system to measure locomotor activity. We found that 80 mg/kg minocycline significantly reduced locomotor activity when administered either alone or injected 30 min prior to cocaine, which increased locomotor activity. To investigate whether minocycline selectively affects the development of locomotor sensitization induced by four daily injections of 10 mg/kg cocaine, we sought a schedule of minocycline administration that does not per se affect locomotor activity. Thus, we selected 40 mg/kg minocycline administered 3 hours prior to cocaine; minocycline did not affect cocaine-stimulated locomotor activity on the first day of administration but prevented the development of cocaine sensitization. We also tested whether minocycline would affect an already established cocaine sensitization. After establishing the sensitization effect by four daily injections, cocaine treatment was discontinued and mice were treated with minocycline daily (days 5–11) or on day 11 only. There was no effect of minocycline treatment on the response of cocaine-sensitized mice to the challenge dose of cocaine on day 11. The mechanisms by which minocycline interferes with the development of cocaine sensitization needs to be characterized.
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影响因子：
3.6
作者：
KOFMAN, O;VANEMBDEN, S;FUCHS, I
通讯作者：
FUCHS, I
影响因子：
7.6
作者：
Uz, T;Akhisaroglu, M;Manev, H
通讯作者：
Manev, H
影响因子：
7.6
作者：
Zhang, Lin;Shirayama, Yukihiko;Hashimoto, Kenji
通讯作者：
Hashimoto, Kenji
影响因子：
3.4
作者：
Gonzalez, Jose Carlos;Egea, Javier;Hernandez-Guijo, Jesus M.
通讯作者：
Hernandez-Guijo, Jesus M.
影响因子：
15.1
作者：
Hutchinson, Mark R.;Northcutt, Alexis L.;Chao, Lindsey W.;Kearney, Jeffrey J.;Zhang, Yingning;Berkelhammer, Debra L.;Loram, Lisa C.;Rozeske, Robert R.;Bland, Sondra T.;Maier, Steven F.;Gleeson, Todd T.;Watkins, Linda R.
通讯作者：
Watkins, Linda R.