DNA copy number alterations in HIV-positive and HIV-negative patients with diffuse large-cell lymphomas.
DNA copy number alterations in HIV-positive and HIV-negative patients with diffuse large-cell lymphomas.
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患有弥漫性大细胞淋巴瘤的 HIV 阳性和 HIV 阴性患者的 DNA 拷贝数变化。
DOI：
10.1097/00126334-200107010-00009
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Jensen,RH
中科院分区：
文献类型：
--
作者：
Tiirikainen,MI;Mullaney,BP;Holly,EA;Pallavicini,MG;Jensen,RH
Individuals infected with HIV are at increased risk of developing aggressive non-Hodgkin's lymphoma with a worse prognosis than those similarly afflicted without HIV infection. The underlying genetic differences in tumor behavior between these two groups are not known. We explored the hypothesis that lymphomas from HIV-positive individuals have distinct somatic genetic changes that may provide clues to the genetic basis of disease progression and outcome. Genome-wide DNA copy number alterations (CNAs) in primary tumors from 14 HIV-positive and 11 HIV-negative patients with diffuse large B-cell lymphoma (DLCL) were quantified using comparative genomic hybridization (CGH). Tumors from HIV-positive patients displayed fewer regional DNA-CNAs than those from patients who did not have HIV. When CNAs were present, they occurred at lower frequency in HIV-positive patients. Gains at chromosomes 8q and Xp were the most frequent changes in the HIV-negative group, and gains on 2p and 12q were common in the combined HIV-positive and HIV-negative groups. No alteration was specific to AIDS-related DLCL. These data suggest that fewer somatic genomic changes are needed for progression to DLCL in HIV-immunocompromised hosts, and that other factors, such as reduced immune surveillance, may contribute to neoplastic progression.
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淋巴恶性肿瘤基因重排的高分辨率分析。
DOI：
--
发表时间：
1999
期刊：
Pathology (Sydney)
影响因子：
--
作者：
J. Ayling;H. Iland
通讯作者：
H. Iland
获得性免疫缺陷综合征相关非霍奇金淋巴瘤的分子病理学。
影响因子：
2.3
作者：
D. Knowles
通讯作者：
D. Knowles
影响因子：
20.3
作者：
Rao, PH;Houldsworth, J;Chaganti, RSK
通讯作者：
Chaganti, RSK
DOI：
--
发表时间：
1995-10
期刊：
The American journal of pathology
影响因子：
--
作者：
J. Isola;O. Kallioniemi;L. Chu;S. Fuqua;S. Hilsenbeck;C. Osborne;F. Waldman
通讯作者：
J. Isola;O. Kallioniemi;L. Chu;S. Fuqua;S. Hilsenbeck;C. Osborne;F. Waldman
染发产品和非霍奇金淋巴瘤的风险：旧金山湾区的一项基于人群的研究。
影响因子：
12.7
作者：
Holly,EA;Lele,C;Bracci,PM
通讯作者：
Bracci,PM