Genomic biomarkers to guide precision radiotherapy in prostate cancer.
Genomic biomarkers to guide precision radiotherapy in prostate cancer.
复制标题
基因组生物标志物指导前列腺癌精确放疗。
DOI：
10.1002/pros.24373
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发表时间：
2022-08
期刊：
影响因子：
2.8
通讯作者：
Tran, Phuoc T.
中科院分区：
文献类型：
--
作者：
Sutera, Philip;Deek, Matthew P.;Van Der Eecken, Kim;Wyatt, Alexander W.;Kishan, Amar U.;Molitoris, Jason K.;Ferris, Matthew J.;Siddiqui, M. Minhaj;Rana, Zaker;Mishra, Mark V.;Kwok, Young;Davicioni, Elai;Spratt, Daniel E.;Ost, Piet;Feng, Felix Y.;Tran, Phuoc T.
我们对癌症患者临床病程的描述能力历来局限于临床、组织病理学和放射学特征。然而，长期以来一直很清楚，仅凭这些数据并不能充分捕捉患者经历的疾病轨迹的异质性和广度。高效基因组测序的出现导致了癌症护理的革命，因为我们试图了解和个性化治疗患者的临床基因组表型。在前列腺癌中，新出现的证据表明，肿瘤基因组学（例如DNA，RNA和表观遗传学）可用于为临床决策提供信息。除了提供有关预后的歧视性信息外，肿瘤基因组学可能也是预测肿瘤治疗反应的关键，可用于进一步定制治疗建议。在此，我们回顾了选择的文献中使用的肿瘤基因组学在前列腺癌的管理，特别是倾向于分析验证和临床测试的基因组生物标志物，用于放射治疗和/或放射治疗的预防性治疗。
Our ability to prognosticate the clinical course of patients with cancer has historically been limited to clinical, histopathological, and radiographic features. It has long been clear however, that these data alone do not adequately capture the heterogeneity and breadth of disease trajectories experienced by patients. The advent of efficient genomic sequencing has led to a revolution in cancer care as we try to understand and personalize treatment specific to patient clinico-genomic phenotypes. Within prostate cancer, emerging evidence suggests that tumor genomics (e.g. DNA, RNA and epigenetics) can be utilized to inform clinical decision making. In addition to providing discriminatory information about prognosis, it is likely tumor genomics also hold a key in predicting response to oncologic therapies which could be used to further tailor treatment recommendations. Herein we review select literature surrounding the use of tumor genomics within the management of prostate cancer, specifically leaning towards analytically validated and clinically tested genomic biomarkers utilized in radiotherapy and/or adjunctive therapies given with radiotherapy.
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影响因子：
3.5
作者：
Scarborough JA;Scott JG
通讯作者：
Scott JG
影响因子：
28.2
作者：
Carreira, Suzanne;Porta, Nuria;Arce-Gallego, Sara;Seed, George;Llop-Guevara, Alba;Bianchini, Diletta;Rescigno, Pasquale;Paschalis, Alec;Bertan, Claudia;Baker, Chloe;Goodall, Jane;Miranda, Susana;Riisnaes, Ruth;Figueiredo, Ines;Ferreira, Ana;Pereira, Rita;Crespo, Mateus;Gurel, Bora;Rodrigues, Daniel Nava;Pettitt, Stephen J.;Yuan, Wei;Serra, Violeta;Rekowski, Jan;Lord, Christopher J.;Hall, Emma;Mateo, Joaquin;de Bono, Johann S.
通讯作者：
de Bono, Johann S.
影响因子：
4.6
作者：
Abida W;Armenia J;Gopalan A;Brennan R;Walsh M;Barron D;Danila D;Rathkopf D;Morris M;Slovin S;McLaughlin B;Curtis K;Hyman DM;Durack JC;Solomon SB;Arcila ME;Zehir A;Syed A;Gao J;Chakravarty D;Vargas HA;Robson ME;Joseph V;Offit K;Donoghue MTA;Abeshouse AA;Kundra R;Heins ZJ;Penson AV;Harris C;Taylor BS;Ladanyi M;Mandelker D;Zhang L;Reuter VE;Kantoff PW;Solit DB;Berger MF;Sawyers CL;Schultz N;Scher HI
通讯作者：
Scher HI
影响因子：
3.2
作者：
Chipidza, Fallon E.;Alshalalfa, Mohammed;Muralidhar, Vinayak
通讯作者：
Muralidhar, Vinayak
影响因子：
4.7
作者：
Bi, Yue;Verginadis, Ioannis I.;Koumenis, Constantinos
通讯作者：
Koumenis, Constantinos