Evidence of increased cardiovascular disease risk in left-handed individuals.
Evidence of increased cardiovascular disease risk in left-handed individuals.
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DOI：
10.3389/fcvm.2023.1326686
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发表时间：
2023
影响因子：
3.6
通讯作者：
Harris, Ryan A.
中科院分区：
文献类型：
--
作者：
Simon, Abigayle B.;Norland, Kimberly;Blackburn, Marsha;Zhao, Sumang;Wang, Xiaoling;Harris, Ryan A.
世界上大约10%的人是左撇子(左撇子)。研究表明，左撇子的人可能比右撇子(RH)的人寿命短。黄体生成素的人似乎也有更多与心血管疾病(CVD)相关的疾病，如糖尿病和癌症。因此，本研究试图验证这一假设，即血管功能和心率变异性(HRV)，这两个心血管风险的关键指标，将低于RH患者。379名参与者，年龄在18-50岁之间。血流介导的扩张(FMD)、血管内皮细胞功能的生物测定和心率变异性(HRV)参数R-R间期的标准差(SDNN)被评估为心血管风险的指标。数据报告为Mean ± SD。12.1%的受试者为黄体生成素。除了RH组高密度脂蛋白较高(p = 0.033)外，两组间在人口学或临床化验值方面没有差异。独立于年龄、性别、种族、体重指数和高密度脂蛋白，LH组(6.1% = ± 3.2%)较RH组(7.6% ±3.8%)FMD值显著降低(p = 0.043)。LH组总功率(p = 0.024)和低频功率(p = 0.003)均低于RH组。LH组SDNN(47.4 ± 18.8 ms)低于RH组(54.7 ± 22.3 ms)(p<0.041)。LH组FMD值与平均动脉压呈负相关(r = −0.517；p <； 0.001)；RH组FMD值与平均动脉压无相关性(p >； 0.001)。与RH组相比，LH组的血管内皮功能和心率变异性较低。此外，FMD与传统的CVD危险因素之间的关系仅在黄体生成素观察到。这些数据支持黄体生成素患者心血管疾病风险增加。
Approximately 10% of the world is left-handed (LH). Research suggests that LH individuals may have shorter lifespans compared to right-handed (RH) individuals. LH individuals also appear to have more cardiovascular disease (CVD) related conditions like diabetes and cancer. Thus, the present study sought to test the hypothesis that vascular function and heart rate variability (HRV), both key indicators of CVD risk, would be lower in LH compared to RH individuals. Three hundred seventy-nine participants, 18–50 years old, were enrolled. Flow-mediated dilation (FMD), a bioassay of vascular endothelial function and standard deviation of R-R interval (SDNN), a parameter of HRV, were evaluated as indices of CVD risk. Data are reported as mean ± SD. 12.1% of the participants were LH. No differences in demographics or clinical laboratory values were observed between groups, except high-density lipoprotein (HDL) was higher (p = 0.033) in RH. FMD was significantly (p = 0.043) lower in LH (6.1% ± 3.2%) compared to RH (7.6% ± 3.8%), independent of age, sex, race, BMI, and HDL. Total power (p = 0.024) and low-frequency power (p = 0.003) were lower in LH compared to RH. Additionally, SDNN was lower (p = 0.041) in LH (47.4 ± 18.8 ms) compared to RH (54.7 ± 22.3 ms). A negative correlation between FMD and mean arterial pressure (r = −0.517; p < 0.001) was observed in LH; no relationships were observed in RH (all p > 0.05). Vascular endothelial function and HRV are lower in LH compared to RH. In addition, relationships between FMD and traditional CVD risk factors were only observed in LH. These data support an increased risk of CVD in LH.
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