ART uptake and adherence among women who use drugs globally: A scoping review.
ART uptake and adherence among women who use drugs globally: A scoping review.
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DOI：
10.1016/j.drugalcdep.2020.108218
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发表时间：
2020-10-01
影响因子：
4.2
通讯作者：
Sherman SG
中科院分区：
文献类型：
--
作者：
Glick JL;Huang A;Russo R;Jivapong B;Ramasamy V;Rosman L;Pelaez D;Footer KHA;Sherman SG
旨在评估有关艾滋病毒阳性吸毒女性 (WWUD) 接受和坚持抗逆转录病毒治疗 (ART) 的同行评审文献状况。根据 PRISMA-ScR 指南，我们对 WWUD 中 ART 的采用和依从性进行了范围界定文献综述，检索了 PubMed、Embase、CINAHL、PsycInfo 和 Sociological Abstracts。资格标准包括：报告 18 岁或以上 WWUD 中至少一项 ART 接受或依从性相关结果； peer-reviewed; 1996年至2018年间以英文出版。我们的搜索发现了 6,735 项研究； 86 人符合资格要求。 ART 的接受率在 30% 到 76% 之间，依从性在 27% 到 95% 之间。药物使用、共病精神疾病和副作用成为该人群接受 ART 和依从性的主要障碍。很少有协调人被确定。这项研究是第一个考察全球 WWUD 中 ART 的接受和依从性的范围审查。采纳和遵守结果的广泛差异表明需要进行黄金标准评估，而高资源环境和低资源环境之间的评估可能有所不同。这项研究主要在个人层面上提供了对吸收和遵守障碍和促进因素的丰富见解。需要更多的研究来检验关注 SEM 其他层面（例如社区和政策层面）的干预措施。这些审查结果可以为 ART 干预措施、未来的研究提供信息，并为 WWUD 的其他支持服务（例如 PrEP 干预措施）提供指导。
To assess the state of peer-reviewed literature surrounding uptake and adherence of antiretroviral therapy (ART) among HIV-positive women who use drugs (WWUD). Consistent with PRISMA-ScR guidelines, we conducted a scoping literature review on ART uptake and adherence among WWUD, searching PubMed, Embase, CINAHL, PsycInfo, and Sociological Abstracts. Eligibility criteria included: reporting at least one ART uptake or adherence related result among WWUD aged 18 or older; peer-reviewed; published in English between 1996-2018. Our search identified 6,735 studies; 86 met eligibility requirements. ART uptake ranged from 30% to 76% and adherence ranged from 27% to 95%. Substance use, co-morbid psychiatric disorders, and side effects emerged as the primary ART uptake and adherence barriers among this population. Few facilitators were identified. This study is the first scoping review to look at ART uptake and adherence among WWUD globally. The wide range in uptake and adherence outcomes indicates the need for gold standard assessments, which may differ between high and low resource settings. This study offers rich insight into uptake and adherence barriers and facilitators, primarily at the intrapersonal level. More research is needed to examine interventions that focus on additional levels of the SEM (e.g., community and policy levels). These review findings can inform ART interventions, future research, and offer guidance to other support services with WWUD, such as PrEP interventions.
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