Examining Relationships between Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy.
Examining Relationships between Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy.
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DOI：
10.1155/2018/6238978
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发表时间：
2018
影响因子：
4.6
通讯作者：
Cassol E
中科院分区：
文献类型：
--
作者：
Ahmed D;Roy D;Cassol E
随着抗逆转录病毒疗法的出现，艾滋病毒感染者现在活得更长、更健康。然而，抗逆转录病毒疗法并不能完全恢复健康，接受治疗的个体患非传染性疾病的比率正在增加，如血脂异常、胰岛素抵抗、2型糖尿病、心血管疾病和非酒精性脂肪肝。虽然众所周知，持续的免疫激活和炎症有助于这些共病疾病的发展，但这种慢性激活的机制仍不完全清楚。在这篇综述中，我们将讨论新出现的证据表明，细胞代谢的改变可能在驱动这种免疫功能障碍的艾滋病毒患者的ART发挥核心作用。
With the advent of antiretroviral therapy (ART), HIV-infected individuals are now living longer and healthier lives. However, ART does not completely restore health and treated individuals are experiencing increased rates of noncommunicable diseases such as dyslipidemia, insulin resistance, type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease. While it is well known that persistent immune activation and inflammation contribute to the development of these comorbid diseases, the mechanisms underlying this chronic activation remain incompletely understood. In this review, we will discuss emerging evidence that suggests that alterations in cellular metabolism may play a central role in driving this immune dysfunction in HIV patients on ART.
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影响因子：
--
作者：
Brown, TT;Cole, SR;Dobs, AS
通讯作者：
Dobs, AS
DOI：
10.1080/09540121.2013.819401
发表时间：
2014-02-01
影响因子：
1.7
作者：
Barber, T. J.;Bradshaw, D.;Catalan, J.
通讯作者：
Catalan, J.
尽管表型激活，HIV诱导的I型干扰素和色氨酸分解代谢驱动T细胞功能障碍。
影响因子：
3.7
作者：
Boasso A;Hardy AW;Anderson SA;Dolan MJ;Shearer GM
通讯作者：
Shearer GM
影响因子：
64.8
作者：
Araki, Koichi;Turner, Alexandra P.;Shaffer, Virginia Oliva;Gangappa, Shivaprakash;Keller, Susanne A.;Bachmann, Martin F.;Larsen, Christian P.;Ahmed, Rafi
通讯作者：
Ahmed, Rafi
影响因子：
6.4
作者：
Blackard, Jason T.;Hiasa, Yoichi;Chung, Raymond T.
通讯作者：
Chung, Raymond T.