Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular metabolism.
Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular metabolism.
复制标题
益气解敏汤通过抑制炎症、恢复Th1/Th2平衡、改善细胞代谢减轻过敏性鼻炎豚鼠模型
DOI：
10.18632/aging.203292
复制
发表时间：
2021-07-27
期刊：
影响因子：
--
通讯作者：
Wu W
中科院分区：
文献类型：
--
作者：
Yan Z;Liu L;Yuan J;Jiao L;Zhou M;Liu J;Wen X;Liu S;Hao P;Liu J;Wu W
We investigated the mechanisms underlying the therapeutic effects of Yiqi Jiemin decoction (YJD), a traditional Chinese medicine (TCM), in the ovalbumin (OVA)-induced allergic rhinitis (AR) model in guinea pigs. YJD significantly decreased infiltration of mast cells and eosinophils into the nasal mucosa of AR model guinea pigs. YJD also increased expression of TGF-β in the nasal mucosa, restored the balance of Th1/Th2 immune cell responses, and decreased serum levels of various pro-inflammatory mediators, including histamine (HA), neuropeptide Y (NPY), acetylcholine (ACH), norepinephrine and immunoglobulin E (IgE). Metabolic analyses using liquid chromatography coupled with high-resolution mass spectrometry revealed that YJD improved cellular metabolism in AR model guinea pigs and increased serum levels of glycocholic acid while decreasing levels 1-palmitoyl lysophosphatidic acid. RNA-sequencing analysis identified BPIFB2 as a potential diagnostic biomarker and therapeutic target for AR. Functional enrichment analyses showed that YJD significantly inhibited cytokine secretion pathways in AR model guinea pigs. These findings demonstrate that YJD protects against OVA-induced AR in guinea pigs by suppressing inflammation in the nasal mucosa, restoring Th1/Th2 balance, and improving cellular metabolism.
登录
查看更多内容
影响因子：
15.3
作者：
Jacobsen, Elizabeth A.;Ochkur, Sergei I.;Pero, Ralph S.;Taranova, Anna G.;Protheroe, Cheryl A.;Colbert, Dana C.;Lee, Nancy A.;Lee, James J.
通讯作者：
Lee, James J.
影响因子：
4.1
作者：
Ren M;Tang Q;Chen F;Xing X;Huang Y;Tan X
通讯作者：
Tan X
影响因子：
14.2
作者：
Shamji, Mohamed H.;Durham, Stephen R.
通讯作者：
Durham, Stephen R.
影响因子：
1.5
作者：
Kaya, Zulkuf;Yayla, Muhammed;Toktay, Erdem
通讯作者：
Toktay, Erdem
不同病原引起的成人社区获得性肺炎患者炎症标志物模式的差异
影响因子：
1.7
作者：
Liu, Meng;Li, Hui;Cao, Bin
通讯作者：
Cao, Bin