Stressful Life Events, ADHD Symptoms, and Brain Structure in Early Adolescence.
Stressful Life Events, ADHD Symptoms, and Brain Structure in Early Adolescence.
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DOI：
10.1007/s10802-018-0443-5
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发表时间：
2019-03
影响因子：
3.6
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Humphreys KL;Watts EL;Dennis EL;King LS;Thompson PM;Gotlib IH
尽管越来越多的人认识到儿童早期的逆境会广泛影响精神病理学的风险，但压力性生活事件对注意力缺陷多动障碍（ADHD）症状发展的贡献尚不清楚。在本研究中，我们研究了压力生活事件的数量和ADHD症状之间的关联，使用儿童行为检查表的注意力问题子量表进行评估，在214名儿童（43%男性）的样本中，年龄为9.11-13.98岁（M=11.38，SD=1.05）。此外，我们还研究了事件发生的时间（即，发病至5岁或6岁后）与ADHD症状相关。最后，我们研究了大脑结构的变化，以确定压力性生活事件是否与大脑区域的体积相关，这些区域被发现作为ADHD症状的函数而变化。我们发现压力性生活事件的数量与ADHD症状之间存在小到中度的关联。虽然事件数量和ADHD症状之间的关联强度没有不同的压力经历发生的年龄的函数，不同的大脑区域之间的关联有牵连的压力源和ADHD症状在两个年龄段期间，压力生活事件发生。这些发现支持了早期逆境与ADHD症状相关的假设，并提供了对这种关联可能的大脑介质的见解。
Despite a growing understanding that early adversity in childhood broadly affects risk for psychopathology, the contribution of stressful life events to the development of symptoms of attention-deficit/hyperactivity disorder (ADHD) is not clear. In the present study, we examined the association between number of stressful life events experienced and ADHD symptoms, assessed using the Attention Problems subscale of the Child Behavior Checklist, in a sample of 214 children (43% male) ages 9.11–13.98 years (M=11.38, SD=1.05). In addition, we examined whether the timing of the events (i.e., onset through age 5 years or after age 6 years) was associated with ADHD symptoms. Finally, we examined variation in brain structure to determine whether stressful life events were associated with volume in brain regions that were found to vary as a function of symptoms of ADHD. We found a small to moderate association between number of stressful life events and ADHD symptoms. Although the strength of the associations between number of events and ADHD symptoms did not differ as a function of the age of occurrence of stressful experiences, different brain regions were implicated in the association between stressors and ADHD symptoms in the two age periods during which stressful life events occurred. These findings support the hypothesis that early adversity is associated with ADHD symptoms, and provide insight into possible brain-based mediators of this association.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
DOI：
10.1016/j.nicl.2017.03.014
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Dennis EL;Faskowitz J;Rashid F;Babikian T;Mink R;Babbitt C;Johnson J;Giza CC;Jahanshad N;Thompson PM;Asarnow RF
通讯作者：
Asarnow RF
影响因子：
6.6
作者：
Brown, George W.;Craig, Tom K. J.;Harvey, Anna L.
通讯作者：
Harvey, Anna L.
影响因子：
3
作者：
Daud, Atia;Rydelius, Per-Anders
通讯作者：
Rydelius, Per-Anders
DOI：
10.1073/pnas.1115365109
发表时间：
2012-04-24
影响因子：
11.1
作者：
Fair, Damien A.;Bathula, Deepti;Nigg, Joel T.
通讯作者：
Nigg, Joel T.