Carotenoid glycosides from cyanobacteria are teratogenic in the zebrafish (Danio rerio) embryo model.
Carotenoid glycosides from cyanobacteria are teratogenic in the zebrafish (Danio rerio) embryo model.
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DOI：
10.1016/j.chemosphere.2017.01.145
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发表时间：
2017-05
期刊：
影响因子：
8.8
通讯作者：
Berry JP
中科院分区：
文献类型：
--
作者：
Jaja-Chimedza A;Sanchez K;Gantar M;Gibbs P;Schmale M;Berry JP
蓝藻的产毒性与几种众所周知的毒素的产生广泛相关，这些毒素对人类和生态系统健康构成公认的威胁，作为淡水富营养化的一部分，以及淡水和沿海栖息地的间歇性水华。然而，大量证据表明，额外的生物活性和潜在的毒性代谢物的贡献。在本研究中，斑马鱼（Danio rerio）胚胎被用作脊椎动物发育的模型，以确定，随后分离和表征，致畸代谢产物从两个代表性菌株的C。拉齐波斯基。使用这种方法，三种化学上相关的类胡萝卜素-特别是叶黄素苷，myxol 2′-糖苷（1），4-酮基myxol 2′-糖苷（2）和4-羟基myxol 2′-糖苷（3）-这是众所周知的色素分子从蓝藻中分离出作为潜在的致畸化合物。类胡萝卜素与视黄酸一起被认为是“类维生素原”，视黄酸是类胡萝卜素氧化裂解的代谢产物，被确立为胚胎发育的关键介质，因此是一种有效的致畸剂。因此，进行了化学上不同的类胡萝卜素以及脱辅基类胡萝卜素和类维生素A的比较毒理学研究。在此基础上，类胡萝卜素的发育毒性的工作模型，作为pro-retinoids的建议，并讨论了这些广泛的代谢产物的致畸性可能对水生脊椎动物种群的影响。
Toxigenicity of cyanobacteria is widely associated with production of several well-described toxins that pose recognized threats to human and ecosystem health as part of both freshwater eutrophication, and episodic blooms in freshwater and coastal habitats. However, a preponderance of evidence indicates contribution of additional bioactive, and potentially toxic, metabolites. In the present study, the zebrafish (Danio rerio) embryo was used as a model of vertebrate development to identify, and subsequently isolate and characterize, teratogenic metabolites from two representative strains of C. raciborskii. Using this approach, three chemically related carotenoids - and specifically the xanthophyll glycosides, myxol 2′-glycoside (1), 4-ketomyxol 2′-glycoside (2) and 4-hydroxymyxol 2′-glycoside (3) - which are, otherwise, well known pigment molecules from cyanobacteria were isolated as potently teratogenic compounds. Carotenoids are recognized “pro-retinoids” with retinoic acid, as a metabolic product of the oxidative cleavage of carotenoids, established as both key mediator of embryo development and, consequently, a potent teratogen. Accordingly, a comparative toxicological study of chemically diverse carotenoids, as well as apocarotenoids and retinoids, was undertaken. Based on this, a working model of the developmental toxicity of carotenoids as pro-retinoids is proposed, and the teratogenicity of these widespread metabolites is discussed in relation to possible impacts on aquatic vertebrate populations.
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发表时间：
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作者：
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