Obesity and urinary incontinence: epidemiology and clinical research update.
Obesity and urinary incontinence: epidemiology and clinical research update.
复制标题
DOI：
10.1016/j.juro.2009.08.071
复制
发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Hunskaar S
中科院分区：
文献类型：
--
作者：
Subak LL;Richter HE;Hunskaar S
我们回顾了肥胖与尿失禁相关的流行病学文献，并总结了减肥对尿失禁影响的临床试验数据。我们系统地检索了已发表的基于社区的患病率研究，并对女性尿失禁与超重/肥胖的相关性进行了双变量或多变量分析。总结了手术、行为和药物减肥对尿失禁影响的病例系列和随机对照试验。流行病学研究表明，肥胖是普遍发生尿失禁的一个强有力的独立危险因素。体重对尿失禁有明显的剂量反应效应，体重指数每增加5个单位，尿失禁风险增加约20%至70%，在对照良好的分析中，体重的最大效应很少超过OR 4至5。在5至10年期间，体重指数每增加5个单位，尿失禁发生的几率增加约30%至60%。体重增加与普遍和偶然发生的压力性尿失禁（包括混合性尿失禁）的相关性可能比与紧迫性尿失禁和膀胱过度活动综合征的相关性更强。减肥研究表明，手术和非手术减肥导致尿失禁症状显着改善。流行病学研究证明超重和肥胖是尿失禁的重要危险因素。通过手术和更保守的方法减轻体重可有效减少尿失禁症状，应强烈考虑将其作为该患者人群的一线治疗。
We reviewed the epidemiological literature on the association of obesity and urinary incontinence, and summarized clinical trial data on the effect of weight loss on urinary incontinence. We systematically searched for published community based prevalence studies with bivariate or multivariate analysis of the association of urinary incontinence and overweight/obesity in women. Case series and randomized controlled trials of the effect of surgical, behavioral and pharmacological weight loss on urinary incontinence are summarized. Epidemiological studies showed that obesity is a strong independent risk factor for prevalent and incident urinary incontinence. There was a clear dose-response effect of weight on urinary incontinence with each 5-unit increase in body mass index associated with about a 20% to 70% increase in the urinary incontinence risk, and the maximum effect of weight rarely exceeded an OR of greater than 4 to 5 on well controlled analyses. The odds of incident urinary incontinence during 5 to 10 years increased by approximately 30% to 60% for each 5-unit increase in body mass index. There may be a stronger association of increasing weight with prevalent and incident stress incontinence, including mixed incontinence, than with urge incontinence and overactive bladder syndrome. Weight loss studies indicated that surgical and nonsurgical weight loss led to significant improvements in urinary incontinence symptoms. Epidemiological studies document overweight and obesity as important risk factors for urinary incontinence. Weight loss by surgical and more conservative approaches is effective to decrease urinary incontinence symptoms and should be strongly considered a first line treatment in this patient population.
登录
查看更多内容
影响因子：
120.7
作者：
Mokdad, AH;Ford, ES;Marks, JS
通讯作者：
Marks, JS
DOI：
10.1080/07315724.1988.10720232
发表时间：
1988-04-01
影响因子：
3.5
作者：
DEITEL, M;STONE, E;SUTHERLAND, DJA
通讯作者：
SUTHERLAND, DJA
影响因子：
9.8
作者：
Danforth, KN;Townsend, MK;Grodstein, F
通讯作者：
Grodstein, F
影响因子：
6.6
作者：
BURGIO, KL;MATTHEWS, KA;ENGEL, BT
通讯作者：
ENGEL, BT
DOI：
10.1111/j.1532-5415.1991.tb02903.x
发表时间：
1991-04-01
影响因子：
6.3
作者：
HUNSKAAR, S;VINSNES, A
通讯作者：
VINSNES, A