Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis.
Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis.
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DOI：
10.1177/0269216318807051
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发表时间：
2019-01
影响因子：
4.4
通讯作者：
Gao W
中科院分区：
文献类型：
--
作者：
Peng JK;Hepgul N;Higginson IJ;Gao W
终末期肝病是世界范围内发病和死亡的常见原因，但对其病理学及其对健康相关生活质量的影响知之甚少。描述终末期肝病患者的症状患病率和健康相关生活质量，以改善护理。系统评价。我们检索了1980年1月至2018年6月期间的8个电子数据库，以研究终末期肝病成人患者的症状患病率或健康相关生活质量。没有语言限制。适当时进行荟萃分析。我们纳入了80项研究：35项评估症状患病率，41项评估健康相关生活质量，4项两者兼而有之。评估症状的工具因研究而异。最常报告的症状如下：疼痛（患病率范围30%-79%）、呼吸困难（20%-88%）、肌肉痉挛（56%-68%）、睡眠障碍（失眠26%-77%，白天嗜睡29.5%-71%）和心理症状（抑郁4.5%-64%，焦虑14%-45%）。勃起功能障碍在男性中普遍存在（53%-93%）。与健康对照组或慢性肝病患者相比，终末期肝病患者的健康相关生活质量显著受损。与代偿性肝硬化相比，失代偿导致36项简表调查的两个组成部分显著恶化，尽管身体组成部分汇总评分的程度更大（从平均6.4（95%置信区间：4.0-8.8）下降; p < 0.001）（4.5（95%置信区间：2.4-6.6）; p < 0.001）。终末期肝病患者的症状患病率与其他晚期疾病患者相似。鉴于症状的多样性和与健康相关的生活质量显着受损，多学科方法和及时干预至关重要。
End-stage liver disease is a common cause of morbidity and mortality worldwide, yet little is known about its symptomatology and impact on health-related quality of life. To describe symptom prevalence and health-related quality of life of patients with end-stage liver disease to improve care. Systematic review. We searched eight electronic databases from January 1980 to June 2018 for studies investigating symptom prevalence or health-related quality of life of adult patients with end-stage liver disease. No language restrictions were applied. Meta-analyses were performed where appropriate. We included 80 studies: 35 assessing symptom prevalence, 41 assessing health-related quality of life, and 4 both. The instruments assessing symptoms varied across studies. The most frequently reported symptoms were as follows: pain (prevalence range 30%–79%), breathlessness (20%–88%), muscle cramps (56%–68%), sleep disturbance (insomnia 26%–77%, daytime sleepiness 29.5%–71%), and psychological symptoms (depression 4.5%–64%, anxiety 14%–45%). Erectile dysfunction was prevalent (53%–93%) in men. The health-related quality of life of patients with end-stage liver disease was significantly impaired when compared to healthy controls or patients with chronic liver disease. Compared with compensated cirrhosis, decompensation led to significant worsening of both components of the 36-Item Short Form Survey although to a larger degree for the Physical Component Summary score (decrease from average 6.4 (95% confidence interval: 4.0–8.8); p < 0.001) than for the Mental Component Summary score (4.5 (95% confidence interval: 2.4–6.6); p < 0.001). The symptom prevalence of patients with end-stage liver disease resembled that of patients with other advanced conditions. Given the diversity of symptoms and significantly impaired health-related quality of life, multidisciplinary approach and timely intervention are crucial.
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影响因子：
3.6
作者：
De Rui, Michele;Schiff, Sami;Montagnese, Sara
通讯作者：
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影响因子：
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通讯作者：
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影响因子：
5.9
作者：
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通讯作者：
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