Multisite causal mediation analysis in the presence of complex sample and survey designs and non‐random non‐response

Multisite causal mediation analysis in the presence of complex sample and survey designs and non‐random non‐response
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存在复杂样本和调查设计以及非随机无响应的多地点因果中介分析

DOI:
10.1111/rssa.12446
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发表时间:
2019
期刊:
Journal of the Royal Statistical Society: Series A (Statistics in Society)
影响因子:
--
通讯作者:
E. Bein
E. Bein
中科院分区:
--
文献类型:
--
作者:
Xu Qin;Guanglei Hong;Jonah Deutsch;E. Bein

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这项研究提供了一个模板,多站点因果调解分析使用一个全面的加权为基础的分析程序,提高外部和内部的有效性。该模板包含一个样本权重以调整复杂的样本和调查设计,采用治疗权重的逆概率以调整不同的治疗分配概率,采用一个估计的无应答权重来解释非随机无应答,并利用一个基于倾向评分的加权策略来灵活地分解总体平均值和总项目影响的研究中心间异质性。由于识别假设并不总是合理的,因此基于加权的平衡检查程序评估了剩余的明显偏倚,而基于加权的敏感性分析进一步评估了与遗漏的混杂因素或倾向评分模型错误指定相关的潜在偏倚。我们推导出的因果效应,占估计权重的抽样不确定性的估计量的渐近方差。该方法适用于重新分析的数据,从全国就业军团的研究。
This study provides a template for multisite causal mediation analysis using a comprehensive weighting‐based analytic procedure that enhances external and internal validity. The template incorporates a sample weight to adjust for complex sample and survey designs, adopts an inverse probability of treatment weight to adjust for differential treatment assignment probabilities, employs an estimated non‐response weight to account for non‐random non‐response and utilizes a propensity‐score‐based weighting strategy to decompose flexibly not only the population average but also the between‐site heterogeneity of the total programme impact. Because the identification assumptions are not always warranted, a weighting‐based balance checking procedure assesses the remaining overt bias, whereas a weighting‐based sensitivity analysis further evaluates the potential bias related to omitted confounding or to propensity score model misspecification. We derive the asymptotic variance of the estimators for the causal effects that account for the sampling uncertainty in the estimated weights. The method is applied to a reanalysis of the data from the National Job Corps Study.
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