Cannabidiol and substance use disorder: Dream or reality.
Cannabidiol and substance use disorder: Dream or reality.
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DOI：
10.1016/j.neuropharm.2022.108948
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发表时间：
2022-04-01
影响因子：
4.7
通讯作者：
Haghparast, Abbas
中科院分区：
文献类型：
--
作者：
Karimi-Haghighi, Saeideh;Razavi, Yasaman;Iezzi, Daniela;Scheyer, Andrew F.;Manzoni, Olivier;Haghparast, Abbas
大麻二醇(CBD)是大麻属植物的主要成分之一，缺乏拟精神和奖赏作用，抑制可卡因、甲基苯丙胺和吗啡等成瘾药物的奖赏和增强作用。此外，CBD的安全性和治疗潜力目前在几种医疗条件下进行评估，包括疼痛、抑郁、运动障碍、癫痫、多发性硬化症、阿尔茨海默病、缺血和物质使用障碍。目前还没有有效的药物使用障碍的治疗方法，本文旨在描述CBD在阿片类药物、精神刺激剂、大麻、酒精和尼古丁滥用的各种模型中的作用的临床前和临床研究。此外，还对CBD治疗药物滥用障碍的可能机制进行了综述。本文对CBD在阿片类药物、精神刺激剂、大麻、酒精和尼古丁等多种药物滥用模式中的作用进行了临床前和临床研究。一些临床前和临床研究表明，CBD可能是一种可靠的药物，可以抑制药物的强化和奖励作用。虽然目前现有的证据表明CBD可以有效地减少成瘾药物的奖赏和增强作用，但在CBD可以被添加到治疗成瘾的治疗武器库之前，还需要更多的临床前和临床研究。
Cannabidiol (CBD) is one of the major constituents of Cannabis sativa L. that lacks psychotomimetic and rewarding properties and inhibits the rewarding and reinforcing effects of addictive drugs such as cocaine, methamphetamine (METH), and morphine. Additionally, CBD’s safety profile and therapeutic potential are currently evaluated in several medical conditions, including pain, depression, movement disorders, epilepsy, multiple sclerosis, Alzheimer’s disease, ischemia, and substance use disorder. There is no effective treatment for substance use disorders such as addiction, and this review aims to describe preclinical and clinical investigations into the effects of CBD in various models of opioid, psychostimulant, cannabis, alcohol, and nicotine abuse. Furthermore, the possible mechanisms underlying the therapeutic potential of CBD on drug abuse disorders are reviewed. The current review considers and summarizes the preclinical and clinical investigations into CBD’s effects in various models of drug abuse include opioids, psychostimulants, cannabis, alcohol, and nicotine. Several preclinical and clinical studies have proposed that CBD may be a reliable agent to inhibit the reinforcing and rewarding impact of drugs. While the currently available evidence converges to suggest that CBD could effectively reduce the rewarding and reinforcing effects of addictive drugs, more preclinical and clinical studies are needed before CBD can be added to the therapeutic arsenal for treating addiction.
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影响因子：
3.8
作者：
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通讯作者：
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