Dystroglycan Suppresses Notch to Regulate Stem Cell Niche Structure and Function in the Developing Postnatal Subventricular Zone.
Dystroglycan Suppresses Notch to Regulate Stem Cell Niche Structure and Function in the Developing Postnatal Subventricular Zone.
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DOI：
10.1016/j.devcel.2016.07.017
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发表时间：
2016-09-12
影响因子：
11.8
通讯作者：
Colognato H
中科院分区：
文献类型：
--
作者：
McClenahan FK;Sharma H;Shan X;Eyermann C;Colognato H
While the extracellular matrix (ECM) is known to regulate neural stem cell quiescence in the adult subventricular zone (SVZ), the function of ECM in the developing SVZ remains unknown. Here, we report that the ECM receptor dystroglycan regulates a unique developmental restructuring of ECM in the early postnatal SVZ. Dystroglycan is furthermore required for ependymal cell differentiation and assembly of niche pinwheel structures, at least in part by suppressing Notch activation in radial glial cells, which leads to the increased expression of MCI, Myb, and FoxJ1, transcriptional regulators necessary for acquisition of the multiciliated phenotype. Dystroglycan also regulates perinatal radial glial cell proliferation and transition into intermediate gliogenic progenitors, such that either acute or constitutive dystroglycan loss-of-function results in increased oligodendrogenesis. These findings reveal a role for dystroglycan in orchestrating both the assembly and function of the SVZ neural stem cell niche. McClenahan and Sharma et al. uncover dystroglycan’s role in driving extracellular matrix reorganization and cellular development during the emergence of the adult subventricular zone neural stem cell niche. During this process dystroglycan helps tune Notch signaling, promoting ependymal cell maturation and the regulated production of glia by niche stem cells.
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影响因子：
30.8
作者：
Lappe-Siefke, C;Goebbels, S;Nave, KA
通讯作者：
Nave, KA
影响因子：
5.3
作者：
Kazanis, Ilias;Lathia, Justin D.;Ffrench-Constant, Charles
通讯作者：
Ffrench-Constant, Charles
DOI：
10.1016/j.cub.2014.08.047
发表时间：
2014-10-06
期刊：
Current biology : CB
影响因子：
--
作者：
Brooks ER;Wallingford JB
通讯作者：
Wallingford JB
影响因子：
1.2
作者：
Kerever, Aurelien;Mercier, Frederic;Nonaka, Risa;de Vega, Susana;Oda, Yuka;Zalc, Bernard;Okada, Yohei;Hattori, Nobutaka;Yamada, Yoshihiko;Arikawa-Hirasawa, Eri
通讯作者：
Arikawa-Hirasawa, Eri
层粘连蛋白聚合诱导受体细胞骨架网络。
影响因子：
7.8
作者：
Colognato, H;Winkelmann, D A;Yurchenco, P D
通讯作者：
Yurchenco, P D