Findings from an in situ Thin-section Sandwich Model for Evaluating Cariogenic and Anti-cariogenic Activity
Findings from an in situ Thin-section Sandwich Model for Evaluating Cariogenic and Anti-cariogenic Activity
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用于评估致龋和抗致龋活性的原位薄片三明治模型的结果
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
N. Grote
中科院分区：
文献类型：
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作者：
J. Mellberg;I. Petrou;N. Grote
本报告总结了8项使用薄切片三明治模型的个体再矿化研究的结果。该模型使用夹在薄塑料片之间的含有龋样病变的人牙釉质（或牙本质）的薄切片，然后将其植入磨牙的颊面中，形成可移除的部分下颌义齿。用氟化钠阳性对照品刷牙两周后，病变的矿化度总是呈阳性，而类似的安慰剂的使用总是产生平均矿物质损失。在大多数研究中，差异显著，p < 0.01。然而，放置在一个单独的口腔标本之间的变化往往很大，甚至包括一个病变获得矿物质，而一个紧密相邻的病变失去minerals.Similarly，平均矿物质的变化产生的个体受试者是不一致的，从一个研究中的净去矿化在另一项研究中的净矿化。然而，所有8项研究的平均矿物质变化表明，使用氟化钠阳性对照品时，所有受试者的矿化程度均高于脱矿程度。所提供的数据显示了许多其他氟化物和非氟化物漱口水和漱口水的薄片病变的矿化，并显示了抗龋齿活性降低的产品（通过几项测试测量）也导致了薄片模型的矿化降低。
This report summarizes the findings from eight individual remineralization studies that used the thin-section sandwich model. This model uses thin sections of human enamel (or dentin) containing caries-like lesions sandwiched between sheets of thin plastic which are then implanted into the buccal surfaces of molars in removable partial mandibular dentures. Toothbrushing with a sodium fluoride-positive control dentifrice for two-week periods always produced positive remineralization of the lesions, and similar use of a placebo always produced mean mineral loss. In most studies, the difference was significant at p < 0.01. However, variation among specimens placed within an individual mouth were often large and even included cases where one lesion gained mineral while a closely adjacent lesion lost mineral. Similarly, mean mineral changes produced by an individual subject were not consistent from study to study and ranged from net demineralization in one study to net remineralization in another study. Nevertheless, mean mineral changes from all eight studies showed that all subjects produced more remineralization than demineralization when using a sodium fluoride-positive control dentifrice. Data are presented showing remineralization of thin-section lesions from a number of other fluoride and non-fluoride dentifrices and mouthrinses and showing that a product with reduced anti-caries activity (as measured by several tests) also resulted in reduced remineralization by the thin-section model.
二膦酸盐对体外和体内牙釉质影响的比较。
影响因子：
4.2
作者：
Wöltgens,JH;Koulourides,T
通讯作者：
Koulourides,T
使用口腔内模型研究氟化物对龋齿发生和进展的影响。
影响因子：
7.6
作者：
Wefel,JS
通讯作者：
Wefel,JS