Transcranial alternating current stimulation affects several alpha components depending on their frequencies relative to the stimulation frequency
Transcranial alternating current stimulation affects several alpha components depending on their frequencies relative to the stimulation frequency
复制标题
经颅交流电刺激会影响几个阿尔法分量，具体取决于它们相对于刺激频率的频率
DOI：
10.1101/2023.02.08.527578
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Amano Kaoru
中科院分区：
文献类型：
--
作者：
Shibusawa Shuka;Kawashima Tomoya;Amano Kaoru
研究背景经颅交流电刺激（transcranial alternating current stimulation，tACS），特别是针对枕叶α振荡的刺激，其后效表现出行为效应和神经反应性的巨大个体差异。我们预测，这种方差至少部分源于这样一个事实，即多个α组件的影响不同的alpha-tACS. ObjectiveTest上述预测，我们从数据中分解了几个α组件，并分别为每个组件和参与者的后效进行评估。更具体地说，我们测试了刺激频率和峰值频率之间的差异如何影响tACS对每个alpha component.MethodsEighteen参与者的后效在不同的日子里接受20分钟的tACS或假刺激。在刺激之前和之后收集10分钟的脑磁图数据，并且以高频分辨率（0.1 Hz）进行频谱分析，以基于峰值频率和空间模式的差异来解开不同的α分量。结果：结果显示了三个频率略有不同的α分量。tACS根据电刺激的相对频率差增加或减少这些α分量的功率。此外，可观察到的组件不同的参与者之间，可能是因为在每个α sources.ConclusionWhen每个α组件不单独分析，在整体α功率的变化将是一个组合的减少或增加的组件，和个体间的差异将变得更大。我们的研究强调了注意到存在多个α成分的重要性，这些成分在实验设计和分析中的峰值频率差异相对较小。
BackgroundThe aftereffects of transcranial alternating current stimulation (tACS), especially targeting occipital alpha oscillations, have been reported to show large individual differences in behavioural effects and neural responsiveness. We predicted that this variance at least partly originates from the fact that multiple alpha components are affected differently by alpha-tACS.ObjectiveTo test the above prediction, we decomposed several alpha components from the data and evaluated the aftereffects separately for each component and participant. More specifically, we tested how the difference between the stimulation frequency and peak frequency influences the aftereffects of tACS on each alpha component.MethodsEighteen participants received 20-min tACS or sham stimulation on separate days. Ten minutes of magnetoencephalography data were collected before and after stimulation, and spectral analysis was performed with a high-frequency resolution (0.1 Hz) to disentangle different alpha components based on the difference in peak frequencies and spatial patterns. Results: The results revealed three alpha components with slightly different frequencies. tACS increased or decreased the power of these alpha components depending on the relative frequency difference from electrical stimulation. Furthermore, observable components differed among participants, possibly because of anatomical differences in each alpha source.ConclusionWhen each alpha component is not analysed separately, the change in overall alpha power will be a combination of decreased or increased components, and inter-individual differences will become larger. Our study highlights the importance of noting the presence of multiple alpha components with relatively small differences in the peak frequency for experimental design and analysis.
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