Transcranial alternating current stimulation enhances individual alpha activity in human EEG.
Transcranial alternating current stimulation enhances individual alpha activity in human EEG.
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DOI：
10.1371/journal.pone.0013766
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发表时间：
2010-11-01
期刊：
影响因子：
3.7
通讯作者：
Herrmann CS
中科院分区：
文献类型：
--
作者：
Zaehle T;Rach S;Herrmann CS
通过经颅直流电刺激（tDCS）对人类皮质进行无创电刺激，在人类皮质功能领域取得了许多重要发现，并已成为评估健康人类参与者大脑功能的成熟方法。最近，经颅交流电刺激（tACS）被引入通过在人类头皮上施加振荡电流来直接调节正在进行的节律性大脑活动。到目前为止，tACS 在调节节律性大脑活动方面的效率仅通过电刺激的感知和行为后果的推断来表明。尚未报道 tACS 的直接电生理学证据。我们对 10 名健康参与者的枕叶皮层进行 tACS，以将神经元振荡活动引入他们各自的 α 频率范围内，并将结果与接受假刺激的另一组参与者的结果进行比较。 tACS 而不是假刺激提高了脑电图顶中央电极中的内源性 α 功率。此外，在尖峰神经元网络中，我们模拟了即使在刺激结束后 tACS 也会受到怎样的影响。结果表明，尖峰时间依赖性可塑性（STDP）根据突触所属神经回路的共振频率选择性地调节突触。因此，tACS 影响 STDP，进而对神经活动产生后遗症。目前的发现是 tACS 与人类皮层持续振荡活动相互作用的第一个直接电生理学证据。这些数据证明了 tACS 特异性调节大脑振荡活动的能力，并显示了其在促进有关大脑振荡功能意义的知识和治疗应用方面的潜力。
Non-invasive electrical stimulation of the human cortex by means of transcranial direct current stimulation (tDCS) has been instrumental in a number of important discoveries in the field of human cortical function and has become a well-established method for evaluating brain function in healthy human participants. Recently, transcranial alternating current stimulation (tACS) has been introduced to directly modulate the ongoing rhythmic brain activity by the application of oscillatory currents on the human scalp. Until now the efficiency of tACS in modulating rhythmic brain activity has been indicated only by inference from perceptual and behavioural consequences of electrical stimulation. No direct electrophysiological evidence of tACS has been reported. We delivered tACS over the occipital cortex of 10 healthy participants to entrain the neuronal oscillatory activity in their individual alpha frequency range and compared results with those from a separate group of participants receiving sham stimulation. The tACS but not the sham stimulation elevated the endogenous alpha power in parieto-central electrodes of the electroencephalogram. Additionally, in a network of spiking neurons, we simulated how tACS can be affected even after the end of stimulation. The results show that spike-timing-dependent plasticity (STDP) selectively modulates synapses depending on the resonance frequencies of the neural circuits that they belong to. Thus, tACS influences STDP which in turn results in aftereffects upon neural activity. The present findings are the first direct electrophysiological evidence of an interaction of tACS and ongoing oscillatory activity in the human cortex. The data demonstrate the ability of tACS to specifically modulate oscillatory brain activity and show its potential both at fostering knowledge on the functional significance of brain oscillations and for therapeutic application.
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DOI：
10.1097/phm.0b013e3181a0e4cb
发表时间：
2009-05-01
影响因子：
3
作者：
Jo, Jung Mi;Kim, Yun-Hee;Lee, Kwang Ho
通讯作者：
Lee, Kwang Ho
影响因子：
3
作者：
Hanslmayr, S;Sauseng, P;Klimesch, W
通讯作者：
Klimesch, W
影响因子：
5.7
作者：
Hanslmayr, Simon;Aslan, Alp;Baeuml, Karl-Heinz
通讯作者：
Baeuml, Karl-Heinz
影响因子：
3.4
作者：
Klimesch, W;Sauseng, P;Gerloff, C
通讯作者：
Gerloff, C
影响因子：
4.4
作者：
Boggio, Paulo S.;Ferrucci, Roberta;Fregni, Felipe
通讯作者：
Fregni, Felipe