Psychosocial stress reactivity is associated with decreased whole-brain network efficiency and increased amygdala centrality.
Psychosocial stress reactivity is associated with decreased whole-brain network efficiency and increased amygdala centrality.
复制标题
DOI：
10.1037/bne0000276
复制
发表时间：
2018-12
影响因子：
1.9
通讯作者：
Knight DC
中科院分区：
文献类型：
--
作者：
Wheelock MD;Rangaprakash D;Harnett NG;Wood KH;Orem TR;Mrug S;Granger DA;Deshpande G;Knight DC
认知和情感功能是由大脑区域的分布式网络协调活动支持的。这种协调活动可能被社会心理压力打乱，导致认知和情绪过程的功能障碍。图论是一种评估协调大脑活动的数学方法，可以估计信息流的效率，并确定更大的分布式神经网络中大脑区域的中心性。然而，将图论技术应用于应力研究的研究有限。推进我们对压力对全球大脑网络影响的理解，可能会为影响压力易感性个体差异的因素提供新的见解。因此，本研究检查了完成蒙特利尔成像压力任务的参与者的大脑连通性。唾液皮质醇、心率、皮肤电导反应和自我报告的压力作为压力的指标，特质焦虑作为被试消极情感倾向的指标。心理社会压力与大脑内信息流动效率的降低有关。此外，在压力暴露期间，调节情绪调节过程的大脑区域（海马体、腹侧前额叶皮层和扣带皮层）的中心性下降。有趣的是，皮质醇反应性的个体差异与该网络内信息流的效率呈负相关，而皮质醇反应性与该网络内杏仁核的中心性呈正相关。这些发现表明，压力降低了信息传递的效率，使调节压力反应的大脑区域的功能容易受到干扰。
Cognitive and emotional functions are supported by the coordinated activity of a distributed network of brain regions. This coordinated activity may be disrupted by psychosocial stress, resulting in the dysfunction of cognitive and emotional processes. Graph theory is a mathematical approach to assess coordinated brain activity that can estimate the efficiency of information flow and determine the centrality of brain regions within a larger distributed neural network. However, limited research has applied graph theory techniques to the study of stress. Advancing our understanding of the impact stress has on global brain networks may provide new insight into factors that influence individual differences in stress susceptibility. Therefore, the present study examined the brain connectivity of participants that completed the Montreal Imaging Stress Task. Salivary cortisol, heart rate, skin conductance response, and self-reported stress served as indices of stress, and trait anxiety served as an index of participant’s disposition towards negative affectivity. Psychosocial stress was associated with a decrease in the efficiency of the flow of information within the brain. Further, the centrality of brain regions that mediate emotion regulation processes (hippocampus, ventral prefrontal cortex, and cingulate cortex) decreased during stress exposure. Interestingly, individual differences in cortisol reactivity were negatively correlated with the efficiency of information flow within this network, whereas cortisol reactivity was positively correlated with the centrality of the amygdala within the network. These findings suggest that stress reduces the efficiency of information transfer and leaves the function of brain regions that regulate the stress response vulnerable to disruption.
登录
查看更多内容
影响因子：
3
作者：
Bach DR;Flandin G;Friston KJ;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
5
作者：
Arnsten, Amy F T;Raskind, Murray A;Taylor, Fletcher B;Connor, Daniel F
通讯作者：
Connor, Daniel F
影响因子：
5.7
作者：
Havlicek M;Jan J;Brazdil M;Calhoun VD
通讯作者：
Calhoun VD
影响因子：
5.7
作者：
Deshpande, Gopikrishna;Sathian, K.;Hu, Xiaoping
通讯作者：
Hu, Xiaoping
影响因子：
2.6
作者：
Allendorfer, Jane B.;Heyse, Heidi;Szaflarski, Jerzy P.
通讯作者：
Szaflarski, Jerzy P.