Default mode and salience network alterations in suicidal and non-suicidal self-injurious thoughts and behaviors in adolescents with depression.
Default mode and salience network alterations in suicidal and non-suicidal self-injurious thoughts and behaviors in adolescents with depression.
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抑郁青少年自杀和非自杀自残想法和行为的默认模式和显著网络改变。
DOI：
10.1038/s41398-020-01103-x
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发表时间：
2021-01-12
影响因子：
6.8
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Ho TC;Walker JC;Teresi GI;Kulla A;Kirshenbaum JS;Gifuni AJ;Singh MK;Gotlib IH
自杀意念（SI）和非自杀性自伤（NSSI）是青少年自杀死亡的两个不同但经常共同发生的危险因素。需要阐明专门表征青少年SI和NSSI的神经生物学模式，以告知在干预研究中使用这些标志物并开发基于大脑的治疗靶点。在这里，我们临床评估了70名青少年-49名青少年抑郁症和21名健康对照-以确定SI和NSSI的历史。28名抑郁青少年有SI病史，29名有NSSI病史（20名重叠）。所有参与者都接受了静息状态fMRI扫描。我们比较了中央执行网络（CEN），默认模式网络（DMN）和显着网络（SN）的细分网络的一致性。我们还研究了网络间连接的组间差异，并探讨了大脑行为的相关性。与没有SI或NSSI的青少年和健康对照组相比，患有SI和NSSI的抑郁青少年的腹侧DMN的一致性较低（所有ps < 0.043，未校正）。与未患NSSI的青少年和健康对照组相比，患有NSSI的抑郁青少年在前DMN和岛叶-SN中的连贯性较低（所有ps < 0.030，未校正），CEN-DMN连接性较高（所有ps < 0.030，未校正）。所有DMN子网络和岛-SN中较低的网络一致性与上个月较高的SI和NSSI相关（所有ps < 0.001，未校正）。因此，在我们的样本中，SI和NSSI都与自我参照处理和未来规划困难相关的大脑网络有关，而NSSI则与内感受性意识中断相关的大脑网络有关。
Suicidal ideation (SI) and non-suicidal self-injury (NSSI) are two distinct yet often co-occurring risk factors for suicide deaths in adolescents. Elucidating the neurobiological patterns that specifically characterize SI and NSSI in adolescents is needed to inform the use of these markers in intervention studies and to develop brain-based treatment targets. Here, we clinically assessed 70 adolescents—49 adolescents with depression and 21 healthy controls—to determine SI and NSSI history. Twenty-eight of the depressed adolescents had a history of SI and 29 had a history of NSSI (20 overlapping). All participants underwent a resting-state fMRI scan. We compared groups in network coherence of subdivisions of the central executive network (CEN), default mode network (DMN), and salience network (SN). We also examined group differences in between-network connectivity and explored brain-behavior correlations. Depressed adolescents with SI and with NSSI had lower coherence in the ventral DMN compared to those without SI or NSSI, respectively, and healthy controls (all ps < 0.043, uncorrected). Depressed adolescents with NSSI had lower coherence in the anterior DMN and in insula-SN (all ps < 0.030, uncorrected), and higher CEN–DMN connectivity compared to those without NSSI and healthy controls (all ps < 0.030, uncorrected). Lower network coherence in all DMN subnetworks and insula-SN were associated with higher past-month SI and NSSI (all ps < 0.001, uncorrected). Thus, in our sample, both SI and NSSI are related to brain networks associated with difficulties in self-referential processing and future planning, while NSSI specifically is related to brain networks associated with disruptions in interoceptive awareness.
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影响因子：
10.6
作者：
Caria, Andrea;Sitaram, Ranganatha;Birbaumer, Niels
通讯作者：
Birbaumer, Niels
DOI：
10.1016/j.pnpbp.2019.109778
发表时间：
2020-04-20
影响因子：
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作者：
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作者：
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通讯作者：
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作者：
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通讯作者：
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