Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment.
Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment.
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十字花科蔬菜的硫烷：改善胶质母细胞瘤治疗的最新进展。
DOI：
10.3390/nu10111755
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发表时间：
2018-11-14
期刊：
影响因子：
5.9
通讯作者：
Morroni F
中科院分区：
文献类型：
--
作者：
Sita G;Hrelia P;Graziosi A;Morroni F
萝卜硫醚(SFN)是一种从十字花科蔬菜中提取的异硫氰酸酯(ITC)，特别是西兰花和西兰花芽，因其在疾病中具有良好的健康促进作用和在正常组织中的低毒而被广泛研究。尽管尚未完全了解，但在癌症发展的每个阶段，许多抗癌活性的机制已被归因于该ITC。鉴于现有关于SFN的有前景的数据，本综述旨在提供SFN与胶质母细胞瘤(GBM)进展相关的细胞机制的潜在活性的概述。基底膜是成人中最常见的恶性脑肿瘤，目前是一种无法治愈的疾病，主要原因是其高度侵袭性的表型，以及现有治疗方法的低疗效。尽管做出了所有努力，接受治疗的GBM患者的中位总存活率仍约为1.5年。因此，迫切需要提供支持，以便将在理解GBM分子背景方面的进展转化为更复杂但有希望的治疗策略，其中SFN可能会发挥主导作用。
Sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables, particularly broccoli and broccoli sprouts, has been widely investigated due to its promising health-promoting properties in disease, and low toxicity in normal tissue. Although not yet fully understood, many mechanisms of anticancer activity at each step of cancer development have been attributed to this ITC. Given the promising data available regarding SFN, this review aimed to provide an overview on the potential activities of SFN related to the cellular mechanisms involved in glioblastoma (GBM) progression. GBM is the most frequent malignant brain tumor among adults and is currently an incurable disease due mostly to its highly invasive phenotype, and the poor efficacy of the available therapies. Despite all efforts, the median overall survival of GBM patients remains approximately 1.5 years under therapy. Therefore, there is an urgent need to provide support for translating the progress in understanding the molecular background of GBM into more complex, but promising therapeutic strategies, in which SFN may find a leading role.
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影响因子：
5.2
作者：
Clarke, John D.;Hsu, Anna;Yu, Zhen;Dashwood, Roderick H.;Ho, Emily
通讯作者：
Ho, Emily
DOI：
10.1002/wnan.1479
发表时间：
2018-01
期刊：
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
影响因子：
--
作者：
Chakroun RW;Zhang P;Lin R;Schiapparelli P;Quinones-Hinojosa A;Cui H
通讯作者：
Cui H
影响因子：
15.9
作者：
Cen, Ling;Carlson, Brett L.;Sarkaria, Jann N.
通讯作者：
Sarkaria, Jann N.
影响因子：
3.6
作者：
Bergantin, Elisa;Quarta, Carmelo;Hrelia, Patrizia
通讯作者：
Hrelia, Patrizia
影响因子：
7.3
作者：
Chen, X.;Liu, J.;Chen, S-Y
通讯作者：
Chen, S-Y