Identification and acitivities of anticoagulants in the salivary glands of the blood sucking kissing bug, Rhodnius prolixus
Identification and acitivities of anticoagulants in the salivary glands of the blood sucking kissing bug, Rhodnius prolixus
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吸血接吻虫Rhodnius prolixus唾液腺中抗凝剂的鉴定及其活性
DOI：
10.7601/mez.47.263
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Y. Chinzei
中科院分区：
文献类型：
--
作者：
M. Yuda;Jianxin Sun;M. Yamaguchi;K. Ando;Y. Chinzei
对吸血吻蝽（Rhodnius Protixus）唾液腺的抗凝活性进行了分析。SG粗提物对活化的部分凝血活素（APTT）有较强的延长活性，对凝血酶原（PT）有较弱的延长活性。分析了SG提取物对固有凝血途径和常见凝血途径因子的抑制作用。SG提取物对ixalvial磷脂（PL）复合物（Xase复合物）具有较高的抑制活性，对丝氨酸蛋白酶、钾化因子、XIIa因子和IIa因子具有较低的抑制活性。而SG提取物对XIa和Xa因子无抑制作用。这些结果表明，SG在内在凝血途径中含有较强的Xase复合物抑制剂，在共同途径中含有对IIa因子的抑制。两种抗凝血因子均为
: Anticeagulant activities of the salivary glands (SG) of the blood sucking kissing bug, Rhodnius Protixus, were analyzed. The crude SG extract showed strong activity to prolong activated partial thromboplastin time (APTT) and also weak activity in elongation of prothrombin time (PT). Inhibition activities of SG ex- tract to the factors in the intrinsic and cornmon coagulation pathways were analyzed. SG extract showed high inhibition activity to the IXalVIIIalphospholipid {PL) complex (Xase complex) and low to serine protease, kallikrein, factor XIIa, and factor IIa. However SG extract did not show inhibition activity to factors XIa and Xa. These results indicate that SG contains a strong inhibitor of Xase complex in the intrinsic coagulation pathway and an inhibitoT of factor IIa in the common pathway. Both anticoagulant factors were
Prolixin S（硝基蛋白 2）的纯化和表征，Prolixin S 是吸血虫 Rhodnius prolixus 的唾液抗凝剂。
DOI：
10.1042/bj3080243
发表时间：
1995
期刊：
The Biochemical journal
影响因子：
--
作者：
Ribeiro,JM;Schneider,M;Guimarães,JA
通讯作者：
Guimarães,JA