Stimulation of ACTH release by naloxone: central or peripheral action?
Stimulation of ACTH release by naloxone: central or peripheral action?
复制标题
纳洛酮刺激 ACTH 释放：中枢作用还是外周作用？
DOI：
10.1016/0024-3205(85)90589-2
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发表时间：
1985
期刊：
影响因子：
6.1
通讯作者：
D. Jezova
中科院分区：
文献类型：
--
作者：
D. Jezova
在雄性大鼠外周给予纳洛酮和甲基溴化纳洛酮（阿片拮抗剂纳洛酮的四级衍生物，认为其不能穿过血脑屏障）后，测定血浆中ACTH和皮质酮的浓度。在0.625-5.0 mg kg-1的剂量范围内，皮下注射甲基溴化纳洛酮导致血浆皮质酮水平小幅但显著增加。通过永久性腹膜内导管向自由活动大鼠注射纳洛酮及其季铵衍生物，可诱导注射后30 min通过永久性尾动脉导管获得的血液中测得的血浆ACTH水平显著升高。这些结果表明，血脑屏障外的位点，至少部分，参与纳洛酮诱导的刺激ACTH释放。
The concentration of ACTH and corticosterone in plasma were measured following peripheral administration of naloxone and naloxone methylbromide (quaternary derivative of opiate antagonist naloxone which is thought not to cross the blood brain barrier) in male rats. Subcutaneous a administration of naloxone methylbromide in the dose range of 0.625–5.0 mg kg-1 resulted in a small but significant increase in plasma corticosterone levels. Both naloxone and its quaternary derivative injected via permanent intraperitoneal catheters to freely moving rats induced a highly significant increase in plasma ACTH levels measured in blood obtained via permanent tail artery catheters 30 min following injection. These results indicate that loci outside the blood brain barrier are, at least partially, involved in the naloxone-induced stimulation of ACTH release.
影响因子：
4.8
作者：
J. Lymangrover;L. Dokas;A. Kong;R. Martín;M. Saffran
通讯作者：
J. Lymangrover;L. Dokas;A. Kong;R. Martín;M. Saffran