Sociability and brain development in BALB/cJ and C57BL/6J mice.
Sociability and brain development in BALB/cJ and C57BL/6J mice.
复制标题
BALB/CJ和C57BL/6J小鼠的社交和大脑发展。
DOI：
10.1016/j.bbr.2011.12.001
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发表时间：
2012-03-17
影响因子：
2.7
通讯作者：
Brodkin, Edward S.
中科院分区：
文献类型：
--
作者：
Fairless, Andrew H.;Dow, Holly C.;Kreibich, Arati Sadalge;Torre, Matthew;Kuruvilla, Mariyam;Gordon, Elliot;Morton, Elizabeth A.;Tan, Junhao;Berrettini, Wade H.;Li, Hongzhe;Abel, Ted;Brodkin, Edward S.
社会性-寻求社会互动的倾向-推动社会认知和社会技能的发展，但在自闭症谱系障碍（ASD）中被破坏。BALB/cJ和C57 BL/6 J近交系小鼠品系分别是低水平和高水平的青少年社会性的有用模型，但是解释品系的对比社会性水平的神经生物学和发育因素在很大程度上是未知的。我们假设BALB/cJ小鼠会随着年龄的增长表现出越来越多的社交能力，但C57 BL/6 J小鼠会在整个发育过程中表现出较高的社交能力。我们还假设，同窝出生的孩子在社交能力上比非同窝出生的孩子更相似。最后，我们假设低社交能力与BALB/cJ小鼠的胼胝体大小和大脑大小增加有关。在19-、23-、31-、42-或70日龄时测试C57 BL/6 J和BALB/cJ小鼠的单独群组的社交性，并测量脑重量和正中矢状胼胝体面积。BALB/cJ的社交能力随着年龄的增长而增加，31和42天之间的社交能力的年龄相互作用的应变表明社交能力发展的青春期的强烈影响。群居性得分聚类根据窝成员在两个菌株，围产期产仔数和性别比被确定为因素，促成了这一集群在C57 BL/6 J，但不是BALB/cJ，窝。胼胝体大小和社交能力之间没有关联，但在BALB/cJ小鼠中，较小的大脑与较低的社交能力相关。这些关联将为未来社会性发展的机制研究提供方向。
Sociability—the tendency to seek social interaction–propels the development of social cognition and social skills, but is disrupted in autism spectrum disorders (ASD). BALB/cJ and C57BL/6J inbred mouse strains are useful models of low and high levels of juvenile sociability, respectively, but the neurobiological and developmental factors that account for the strains’ contrasting sociability levels are largely unknown. We hypothesized that BALB/cJ mice would show increasing sociability with age but that C57BL/6J mice would show high sociability throughout development. We also hypothesized that littermates would resemble one another in sociability more than non-littermates. Finally, we hypothesized that low sociability would be associated with low corpus callosum size and increased brain size in BALB/cJ mice. Separate cohorts of C57BL/6J and BALB/cJ mice were tested for sociability at 19-, 23-, 31-, 42-, or 70-days-of-age, and brain weights and mid-sagittal corpus callosum area were measured. BALB/cJ sociability increased with age, and a strain by age interaction in sociability between 31 and 42 days of age suggested strong effects of puberty on sociability development. Sociability scores clustered according to litter membership in both strains, and perinatal litter size and sex ratio were identified as factors that contributed to this clustering in C57BL/6J, but not BALB/cJ, litters. There was no association between corpus callosum size and sociability, but smaller brains were associated with lower sociability in BALB/cJ mice. The associations reported here will provide directions for future mechanistic studies of sociability development.
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影响因子：
10.6
作者：
Alter MD;Gilani AI;Champagne FA;Curley JP;Turner JB;Hen R
通讯作者：
Hen R
DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
DOI：
10.1530/jrf.0.0950783
发表时间：
1992-08-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
BRUCE, NW;WELLSTEAD, JR
通讯作者：
WELLSTEAD, JR
影响因子：
2.7
作者：
Dahlhaus, Regina;El-Husseini, Alaa
通讯作者：
El-Husseini, Alaa
影响因子：
4.7
作者：
Chadman, Kathryn K.;Gong, Shiaoching;Crawley, Jacqueline N.
通讯作者：
Crawley, Jacqueline N.