Hierarchical organization of gamma and theta oscillatory dynamics in schizophrenia.
Hierarchical organization of gamma and theta oscillatory dynamics in schizophrenia.
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DOI：
10.1016/j.biopsych.2012.01.016
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发表时间：
2012-05-15
影响因子：
10.6
通讯作者：
Light, Gregory A.
中科院分区：
文献类型：
--
作者：
Kirihara, Kenji;Rissling, Anthony J.;Swerdlow, Neal R.;Braff, David L.;Light, Gregory A.
关键词：
精神分裂症患者在广泛的重要认知和临床领域都有缺陷。伽马频率范围（~40 Hz）内振荡的同步与许多正常认知功能相关，并且是精神分裂症患者中观察到的至少一些缺陷的基础。最近的研究表明，伽玛振荡的相位调制的θ波，这种交叉频率耦合表明，一个复杂的和层次的组织控制神经振荡动力学。本研究的目的是确定精神分裂症患者是否有异常的振幅，同步性和交叉频率耦合的伽玛和θ振荡响应于伽玛频率稳态刺激，如果异常的神经振荡动力学与精神分裂症的认知缺陷。精神分裂症患者（n = 234）和健康对照组（n = 188）进行EEG测试，以响应40 Hz的听觉稳态刺激。认知功能进行了评估与电池的神经心理测试。精神分裂症患者有显着减少γ试验间相位相干性，增加θ振幅，和完整的交叉频率耦合相对于健康对照组。在精神分裂症患者中，θ波振幅增加与言语记忆表现差有关。结果表明，精神分裂症患者有特定的改变，在伽马和θ振荡，但这些赤字发生在一个完整的层次组织的上下文中，他们的交叉频率调制响应于40 Hz的稳态刺激。皮层振荡动力学可能有助于理解精神分裂症不同认知和功能障碍的神经机制。
Schizophrenia patients have deficits across a broad range of important cognitive and clinical domains. Synchronization of oscillations in the gamma frequency range (~40 Hz) is associated with many normal cognitive functions and underlies at least some of the deficits observed in schizophrenia patients. Recent studies have demonstrated that gamma oscillations are modulated by the phase of theta waves, and this cross-frequency coupling indicates that a complex and hierarchical organization governs neural oscillatory dynamics. The aims of the present study were to determine if schizophrenia patients have abnormalities in the amplitude, synchrony, and cross-frequency coupling of gamma and theta oscillations in response to gamma-frequency steady-state stimulation and if abnormal neural oscillatory dynamics are associated with cognitive deficits in schizophrenia. Schizophrenia patients (n = 234) and healthy control subjects (n = 188) underwent EEG testing in response to 40-Hz auditory steady-state stimulation. Cognitive functions were assessed with a battery of neuropsychological tests. Schizophrenia patients had significantly reduced gamma intertrial phase coherence, increased theta amplitude, and intact cross-frequency coupling relative to healthy control subjects. In schizophrenia patients, increased theta amplitude was associated with poor verbal memory performance. Results suggest that schizophrenia patients have specific alterations in both gamma and theta oscillations but these deficits occur in the context of an intact hierarchical organization of their cross-frequency modulation in response to 40 Hz steady-state stimulation. Cortical oscillatory dynamics may be useful for understanding the neural mechanisms that underlie the disparate cognitive and functional impairments of schizophrenia.
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影响因子：
3
作者：
Basar-Eroglu, Canan;Brand, Andreas;Schmiedt, Christina
通讯作者：
Schmiedt, Christina
DOI：
10.1073/pnas.86.5.1698
发表时间：
1989-03-01
影响因子：
11.1
作者：
GRAY, CM;SINGER, W
通讯作者：
SINGER, W
影响因子：
3
作者：
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通讯作者：
Cohen, Michael X.
DOI：
10.1073/pnas.0609440103
发表时间：
2006-12-26
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
3
作者：
Demiralp, Tamer;Bayraktaroglu, Zubeyir;Herrmann, Christoph S.
通讯作者：
Herrmann, Christoph S.