A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction.
A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction.
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一种新型的可溶性环氧化物水解酶疫苗可保护鼠心肌免受心肌梗塞。
DOI：
10.1038/s41598-022-10641-x
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发表时间：
2022-04-28
影响因子：
4.6
通讯作者：
Node, Koichi
中科院分区：
文献类型：
--
作者：
Kitsuka, Takahiro;Shiraki, Aya;Oyama, Jun-ichi;Nakagami, Hironori;Tanaka, Atsushi;Node, Koichi
心肌梗死仍然是一种危及生命的疾病，尽管其预后已通过经皮冠状动脉介入治疗和药物治疗的发展得到改善。此外，心肌梗死后重构引起的心力衰竭需要终生治疗。本研究的目的是开发一种新的治疗方法来抑制心肌梗死造成的心肌损伤。我们重点研究了抑制可溶性环氧化物水解酶以延长环氧二碳三烯酸的激活，环氧二碳三烯酸具有血管扩张和抗炎特性。我们成功研制了一种灭活可溶性环氧化物水解酶的新疫苗，并在大鼠心肌梗死模型中对疫苗的效果进行了评价。接种组缺血面积明显减少，心功能明显保留。疫苗治疗明显增加了边界区微血管，抑制了继发性心肌梗死的纤维化。这种可溶性环氧化物水解酶疫苗是一种改善心肌梗死后心功能的新疗法。
Myocardial infarction is still a life-threatening disease, even though its prognosis has been improved through the development of percutaneous coronary intervention and pharmacotherapy. In addition, heart failure due to remodeling after myocardial infarction requires lifelong management. The aim of this study was to develop a novel treatment suppressing the myocardial damage done by myocardial infarction. We focused on inhibition of soluble epoxide hydrolase to prolong the activation of epoxyeicosatrienoic acids, which have vasodilatory and anti-inflammatory properties. We successfully made a new vaccine to inactivate soluble epoxide hydrolase, and we have evaluated the effect of the vaccine in a rat myocardial infarction model. In the vaccinated group, the ischemic area was significantly reduced, and cardiac function was significantly preserved. Vaccine treatment clearly increased microvessels in the border area and suppressed fibrosis secondary to myocardial infarction. This soluble epoxide hydrolase vaccine is a novel treatment for improving cardiac function following myocardial infarction.
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DOI：
10.1136/heartjnl-2016-309983
发表时间：
2016-12-15
期刊：
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影响因子：
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