Inflammation, the Acute Phase Response and Atherosclerosis

Inflammation, the Acute Phase Response and Atherosclerosis
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炎症、急性期反应和动脉粥样硬化

DOI:
10.1515/cclm.1999.080
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发表时间:
1999
期刊:
Nihon Shishubyo Gakkai Kaishi (journal of The Japanese Society of Periodontology)
影响因子:
--
通讯作者:
N. Rifai
N. Rifai
中科院分区:
--
文献类型:
--
作者:
J. Whicher;L. Biasucci;N. Rifai

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越来越多的证据表明,动脉粥样硬化是一种由多种过程共同引起的慢性炎症性疾病,这种炎症的急性加重与急性冠状动脉综合征(如心肌梗死和不稳定型心绞痛)有关。测定血清急性期蛋白水平,如c反应蛋白和血清淀粉样蛋白A,已被用于预测动脉粥样硬化患者急性事件的风险。前瞻性研究表明,血清急性期蛋白水平较高(通常在参考范围内)与心肌梗死(MI)、中风或周围血管疾病的风险增加相关,并可预测高危患者的梗死和死亡风险。这些观察结果对患者的评估和治疗具有重要意义。
Abstract There is increasing evidence that atherosclerosis is a chronic inflammatory disorder resulting from a combination of processes, and that acute exacerbations of this inflammation are associated with the acute coronary syndromes such as myocardial infarction and unstable angina. Measurement of the serum level of acute phase proteins, such as C-reactive protein and serum amyloid A protein, has been used to predict the risk of acute events in patients with atherosclerosis. Prospective studies have shown that higher serum acute phase protein levels, often within the reference range, are associated with increased risk of myocardial infarction (MI), stroke or peripheral vascular disease and predict risk of infarction and death among high-risk patients. These observations have important implications for the assessment of patients and for treatment.
DOI: 10.1161/01.atv.17.6.1121
发表时间: 1997-06-01
影响因子: 8.7
作者:
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