Fibromyalgia and the serotonin pathway.

Fibromyalgia and the serotonin pathway.
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纤维肌痛和血清素途径。

DOI:
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发表时间:
1998
期刊:
Alternative medicine review : a journal of clinical therapeutic
影响因子:
--
通讯作者:
J. Juhl
J. Juhl
中科院分区:
--
文献类型:
--
作者:
J. Juhl

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纤维肌痛综合征是一种肌肉骨骼疼痛和疲劳障碍,表现为弥漫性肌痛、局部压痛、疲劳、痛阈降低和非恢复性睡眠。来自多个来源的证据支持纤维肌痛患者通过5-羟色胺途径的流量减少的概念。通过L-色氨酸或5-羟色氨酸(5-HTP)补充血清素底物已被证明可改善多种患者队列中的抑郁、焦虑、失眠和躯体疼痛的症状。识别低血清色氨酸和血清素水平可能是一个简单的方法来确定人谁会对这种方法反应良好。
Fibromyalgia syndrome is a musculoskeletal pain and fatigue disorder manifested by diffuse myalgia, localized areas of tenderness, fatigue, lowered pain thresholds, and nonrestorative sleep. Evidence from multiple sources support the concept of decreased flux through the serotonin pathway in fibromyalgia patients. Serotonin substrate supplementation, via L-tryptophan or 5-hydroxytryptophan (5-HTP), has been shown to improve symptoms of depression, anxiety, insomnia and somatic pains in a variety of patient cohorts. Identification of low serum tryptophan and serotonin levels may be a simple way to identify persons who will respond well to this approach.
大鼠腰背根无髓鞘初级传入轴突的肽免疫反应性。
DOI: 10.1177/37.7.2471724
发表时间: 1989
期刊: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
影响因子: --
作者:
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通讯作者: Coggeshall,RE
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