Striatal cholinergic interneurons and Parkinson's disease.
Striatal cholinergic interneurons and Parkinson's disease.
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DOI：
10.1111/ejn.13638
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Surmeier DJ
中科院分区：
文献类型：
--
作者：
Tanimura A;Pancani T;Lim SAO;Tubert C;Melendez AE;Shen W;Surmeier DJ
巨大的胆碱能中间神经元（ChIs）长期以来被认为是纹状体回路中控制目标导向行为和习惯的关键节点。近年来，新的实验方法，如光遗传学和单突触狂犬病毒作图，扩大了我们对ChIs如何影响纹状体活动的理解，这些纹状体活动是行为选择的基础，以及多巴胺能和胆碱能信号传导的相互作用。这些方法也开始揭示ChI功能在影响基底神经节的疾病状态下是如何扭曲的，比如帕金森病（PD）。这篇综述简要概述了我们目前对ChIs在纹状体生理学中所起的功能作用的理解以及这种作用在帕金森病中的变化。这些发现的转化意义，以及仍有待弥合的差距，也进行了讨论。胆碱能中间神经元（ChIs）在调节纹状体回路中起着重要作用。除了整合皮质和丘脑谷氨酸能输入外，ChIs还整合纹状体内gaba能信号和神经调节信号，包括来自多巴胺能神经元的信号。ChIs的输出通过毒蕈碱和烟碱受体的混合物调节几乎所有纹状体细胞类型。
Giant, aspiny cholinergic interneurons (ChIs) have long been known to be key nodes in the striatal circuitry controlling goal directed actions and habits. In recent years, new experimental approaches, like optogenetics and monosynaptic rabies virus mapping, have expanded our understanding of how ChIs contribute to the striatal activity underlying action selection and the interplay of dopaminergic and cholinergic signaling. These approaches also have begun to reveal how ChI function is distorted in disease states affecting the basal ganglia, like Parkinson’s disease (PD). This review gives a brief overview of our current understanding of the functional role played by ChIs in striatal physiology and how this changes in PD. The translational implications of these discoveries, as well as the gaps that remain to be bridged, are discussed as well. Cholinergic interneurons (ChIs) play an important role in regulating the striatal circuit. In addition to integrating cortical and thalamic glutamatergic input, ChIs integrate intrastriatal GABAergic signals and neuromodulatory signals, including those from dopaminergic neurons. The output of ChIs modulates nearly all striatal cell types through a mixture of muscarinic and nicotinic receptors.
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DOI：
10.1196/annals.1390.006
发表时间：
2007-01-01
期刊：
REWARD AND DECISION MAKING IN CORTICOBASAL GANGLIA NETWORKS
影响因子：
--
作者：
Balleine, Bernard W.;Ostlund, Sean B.
通讯作者：
Ostlund, Sean B.
DOI：
10.1196/annals.1390.2226
发表时间：
2007-01-01
期刊：
REWARD AND DECISION MAKING IN CORTICOBASAL GANGLIA NETWORKS
影响因子：
--
作者：
Balleine, Bernard W.;Doya, Kenji;Sakagami, Masamichi
通讯作者：
Sakagami, Masamichi
影响因子：
5.3
作者：
Bennett, BD;Callaway, JC;Wilson, CJ
通讯作者：
Wilson, CJ
影响因子：
5.3
作者：
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通讯作者：
Kawaguchi, Y
影响因子：
3.3
作者：
Bell, MI;Richardson, PJ;Lee, K
通讯作者：
Lee, K