Exposure contrasts associated with a liquefied petroleum gas (LPG) intervention at potential field sites for the multi-country household air pollution intervention network (HAPIN) trial in India: results from pilot phase activities in rural Tamil Nadu.
Exposure contrasts associated with a liquefied petroleum gas (LPG) intervention at potential field sites for the multi-country household air pollution intervention network (HAPIN) trial in India: results from pilot phase activities in rural Tamil Nadu.
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DOI：
10.1186/s12889-020-09865-1
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发表时间：
2020-11-26
影响因子：
4.5
通讯作者：
Balakrishnan K
中科院分区：
文献类型：
--
作者：
Sambandam S;Mukhopadhyay K;Sendhil S;Ye W;Pillarisetti A;Thangavel G;Natesan D;Ramasamy R;Natarajan A;Aravindalochanan V;Vinayagamoorthi A;Sivavadivel S;Uma Maheswari R;Balakrishnan L;Gayatri S;Nargunanathan S;Madhavan S;Puttaswamy N;Garg SS;Quinn A;Rosenthal J;Johnson M;Liao J;Steenland K;Piedhrahita R;Peel J;Checkley W;Clasen T;Balakrishnan K
家庭空气污染干预网络（HAPIN）试验旨在评估液化石油气（LPG）烹饪燃料和炉灶干预对四个低收入和中等收入国家（LMIC）妇女和儿童的健康益处。我们在印度潜在的HAPIN现场测量了在生物质或液化石油气烹饪燃料使用的替代条件下可实现的女性暴露对比，以帮助主要试验的场地选择。我们从印度泰米尔纳德邦维卢普拉姆和Nagapattinam地区的潜在现场招募了参与者，这些现场是在可行性评估期间确定的。我们表演了。(i)对使用生物质或液化石油气作为主要烹饪燃料的妇女（N = 79）进行横断面测量，以及（ii）对孕妇（N = 41）进行前后测量，一次在使用生物质燃料的基线时，两次-在安装液化石油气炉灶和免费燃料干预后的1个月和2个月。我们让参与者共同设计服装和仪器的立场，为个人和区域采样。我们测量了24或48小时的个人暴露和厨房和环境浓度的细颗粒物（PM2.5）使用重量采样器。在横断面分析中，使用家庭的生物质和液化石油气的厨房PM2.5浓度中位数（四分位距，IQR）分别为134 μg/m3 [IQR：71-258]和27 μg/m3 [IQR：20-47]，而相应的个人暴露分别为75 μg/m3 [IQR：55-104]和36 μg/m3 [IQR：26-46]。在之前和之后的分析中，孕妇的中位48小时个人暴露量在基线时为72 μg/m3 [IQR：49-127]，LPG干预后为25 μg/m3 [IQR：18-35]，在2个月的干预期间，平均厨房PM2.5浓度持续下降93%，平均个人PM2.5暴露持续下降78%。中位环境浓度为23 μg/m3 [IQR：19-27）。参与者的反馈对于设计服装和乐器架至关重要，以确保高度合规。在印度的HAPIN试验现场，液化石油气炉灶和燃料干预被认为适合于实现与健康相关的接触减少。环境浓度表明其他来源的贡献有限。研究结果为印度HAPIN试验地点的选择提供了关键信息，同时也为LMIC孕妇中与LPG干预相关的HAP暴露提供了新信息。ClinicalTrials.Gov. NCT 02944682; Proximal于2016年10月17日注册。在线版本包含补充材料，可通过10.1186/s12889-020-09865-1获得。
The Household Air Pollution Intervention Network (HAPIN) trial aims to assess health benefits of a liquefied petroleum gas (LPG) cookfuel and stove intervention among women and children across four low- and middle-income countries (LMICs). We measured exposure contrasts for women, achievable under alternative conditions of biomass or LPG cookfuel use, at potential HAPIN field sites in India, to aid in site selection for the main trial. We recruited participants from potential field sites within Villupuram and Nagapattinam districts in Tamil Nadu, India, that were identified during a feasibility assessment. We performed. (i) cross-sectional measurements on women (N = 79) using either biomass or LPG as their primary cookfuel and (ii) before-and-after measurements on pregnant women (N = 41), once at baseline while using biomass fuel and twice – at 1 and 2 months – after installation of an LPG stove and free fuel intervention. We involved participants to co-design clothing and instrument stands for personal and area sampling. We measured 24 or 48-h personal exposures and kitchen and ambient concentrations of fine particulate matter (PM2.5) using gravimetric samplers. In the cross-sectional analysis, median (interquartile range, IQR) kitchen PM2.5 concentrations in biomass and LPG using homes were 134 μg/m3 [IQR:71–258] and 27 μg/m3 [IQR:20–47], while corresponding personal exposures were 75 μg/m3 [IQR:55–104] and 36 μg/m3 [IQR:26–46], respectively. In before-and-after analysis, median 48-h personal exposures for pregnant women were 72 μg/m3 [IQR:49–127] at baseline and 25 μg/m3 [IQR:18–35] after the LPG intervention, with a sustained reduction of 93% in mean kitchen PM2.5 concentrations and 78% in mean personal PM2.5 exposures over the 2 month intervention period. Median ambient concentrations were 23 μg/m3 [IQR:19–27). Participant feedback was critical in designing clothing and instrument stands that ensured high compliance. An LPG stove and fuel intervention in the candidate HAPIN trial field sites in India was deemed suitable for achieving health-relevant exposure reductions. Ambient concentrations indicated limited contributions from other sources. Study results provide critical inputs for the HAPIN trial site selection in India, while also contributing new information on HAP exposures in relation to LPG interventions and among pregnant women in LMICs. ClinicalTrials.Gov. NCT02944682; Prospectively registered on October 17, 2016. The online version contains supplementary material available at 10.1186/s12889-020-09865-1.
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