Raman Spectroscopic Tools to Probe the Skin-(Trans)dermal Formulation Interface.
Raman Spectroscopic Tools to Probe the Skin-(Trans)dermal Formulation Interface.
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DOI：
10.1021/acs.molpharmaceut.2c00480
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发表时间：
2022-11-07
影响因子：
4.9
通讯作者：
Guy, Richard H.
中科院分区：
文献类型：
--
作者：
Garvie-Cook, Hazel;Hoppel, Magdalena;Guy, Richard H.
关键词：
设计用于将活性药物成分输送到皮肤内或通过皮肤的药物（通常分别称为局部用药和透皮用药）通常被认为是复杂的药品。这些制剂面临的一个特殊挑战是确定一种合适的方法（理想情况下，在特异性、准确性、精密度和稳健性方面）或方法组合来评估药物递送至目标部位的量和速率。目前的重要研究旨在确定和验证相关的微创技术，这些技术可用于量化皮肤不同部位内达到的药物水平以及药物被吸收到皮肤中并从皮肤清除进入体循环的动力学。在这里，说明了共聚焦拉曼显微光谱和成像的应用，以询问与局部和透皮药物产品在制剂-皮肤界面处的性能相关的事件。可视化、深度切片和分析用于 (a) 阐明输送系统和皮肤的关键化学性质，这些化学性质会影响它们的相互作用以及药物从一种药物转移到另一种药物的方式，(b) 在应用和涂抹到皮肤后将药物产品从制造的药物产品转化为残留相（包括活性化合物溶解度发生重要变化的可能性），以及 (c) 药物吸收到皮肤中及其随后“清除”到更深的部位层及以上。总体而言，所描述的拉曼工具提供了对局部和透皮药物产品性能的定性和潜在的半定量见解，并提供了对配方改进和优化有用的信息。
Medicines designed to deliver the active pharmaceutical ingredient either into or through the skin—often referred to as topicals and transdermals, respectively—are generally considered to be complex drug products. A particular challenge faced by these formulations is identifying a suitable method (ideally, in terms of specificity, accuracy, precision, and robustness) or combination of methods with which to assess the amount and rate of drug delivery to the target site. Significant research currently aims to identify and validate relevant and minimally invasive techniques that can be used to quantify both the levels of the drug attained within different parts of the skin and the kinetics with which the drug is taken up into the skin and cleared therefrom into the systemic circulation. Here, the application of confocal Raman microspectroscopy and imaging to interrogate events integral to the performance of topical and transdermal drug products at the formulation-skin interface is illustrated. Visualization, depth slicing, and profiling are used (a) to elucidate key chemical properties of both the delivery system and the skin that have impact on their interaction and the manner in which drug transfer from one to the other may occur, (b) for the transformation of a drug product from that manufactured into a residual phase post-application and inunction into the skin (including the potential for important changes in solubility of the active compound), and (c) for drug absorption into the skin and its subsequent ‘“clearance” into deeper layers and beyond. Overall, the Raman tools described offer both qualitative and potentially semi-quantitative insights into topical and transdermal drug product performance and provide information useful for formulation improvement and optimization.
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应用共聚焦拉曼显微镜表征局部半固体制剂及其对人体皮肤的体外渗透。
影响因子：
3.7
作者：
Jung, Nathalie;Namjoshi, Sarika;Mohammed, Yousuf;Grice, Jeffrey E.;Benson, Heather A. E.;Raney, Sam G.;Roberts, Michael S.;Windbergs, Maike
通讯作者：
Windbergs, Maike
DOI：
10.1208/s12248-021-00571-3
发表时间：
2021-03-29
期刊：
The AAPS journal
影响因子：
--
作者：
Hoppel M;Tabosa MAM;Bunge AL;Delgado-Charro MB;Guy RH
通讯作者：
Guy RH
影响因子：
7.4
作者：
Wanjiku, Barbara;Yamamoto, Kenji;Schaefer-Korting, Monika
通讯作者：
Schaefer-Korting, Monika
影响因子：
5.4
作者：
Iliopoulos F;Caspers PJ;Puppels GJ;Lane ME
通讯作者：
Lane ME
影响因子：
10.8
作者：
Garvie-Cook, Hazel;Frederiksen, Kit;Gordeev, Sergey N.
通讯作者：
Gordeev, Sergey N.