Application of Confocal Raman Microscopy for the Characterization of Topical Semisolid Formulations and their Penetration into Human Skin Ex Vivo.
Application of Confocal Raman Microscopy for the Characterization of Topical Semisolid Formulations and their Penetration into Human Skin Ex Vivo.
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应用共聚焦拉曼显微镜表征局部半固体制剂及其对人体皮肤的体外渗透。
DOI：
10.1007/s11095-022-03245-7
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发表时间：
2022-05
影响因子：
3.7
通讯作者：
Windbergs, Maike
中科院分区：
文献类型：
--
作者：
Jung, Nathalie;Namjoshi, Sarika;Mohammed, Yousuf;Grice, Jeffrey E.;Benson, Heather A. E.;Raney, Sam G.;Roberts, Michael S.;Windbergs, Maike
大多数药品的质量检测和批准程序是一个简化的过程，具有确定关键质量属性的标准化程序。然而，用于局部药物递送的半固体剂型的评价仍然是一项具有挑战性的任务。这里提出的工作突出共焦拉曼显微镜（CRM）作为一个有价值的工具，这些产品的特性。CRM是一种基于激光的方法，结合化学选择性分析和高分辨率成像，用于评价不同的市售局部阿昔洛韦乳膏。我们表明，CRM使空间分辨分析的半固体产品的微观结构特征，并提供深入了解药物分布和多晶型状态以及赋形剂的组成和安排。此外，我们探讨CRM如何可以用来监测相分离，并研究皮肤渗透和新鲜和冷冻保存切除的人体皮肤组织的相互作用。这项研究提出了一个全面的概述和说明CRM如何可以促进几种类型的关键分析半固体外用制剂及其相互作用与其生物靶点，说明CRM是一个有用的工具，研究，开发以及在制药行业的质量检测。
The quality testing and approval procedure for most pharmaceutical products is a streamlined process with standardized procedures for the determination of critical quality attributes. However, the evaluation of semisolid dosage forms for topical drug delivery remains a challenging task. The work presented here highlights confocal Raman microscopy (CRM) as a valuable tool for the characterization of such products. CRM, a laser-based method, combining chemically-selective analysis and high resolution imaging, is used for the evaluation of different commercially available topical acyclovir creams. We show that CRM enables the spatially resolved analysis of microstructural features of semisolid products and provides insights into drug distribution and polymorphic state as well as the composition and arrangement of excipients. Further, we explore how CRM can be used to monitor phase separation and to study skin penetration and the interaction with fresh and cryopreserved excised human skin tissue. This study presents a comprehensive overview and illustration of how CRM can facilitate several types of key analyses of semisolid topical formulations and of their interaction with their biological target site, illustrating that CRM is a useful tool for research, development as well as for quality testing in the pharmaceutical industry.
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作者：
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通讯作者：
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DOI：
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发表时间：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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