Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis.
Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis.
复制标题
DOI：
10.1016/j.isci.2022.105004
复制
发表时间：
2022-09-16
期刊：
影响因子：
5.8
通讯作者：
Cong, Yingzi
中科院分区：
文献类型：
--
作者：
Yu, Yu;Yang, Wenjing;Yu, Tianming;Zhao, Xiaojing;Zhou, Zheng;Yu, Yanbo;Xiong, Lifeng;Yang, Hui;Bilotta, Anthony J.;Yao, Suxia;Golovko, George;Plasencia, Agustin;Quintana, Francisco J.;Zhou, Liang;Li, Yanqing;Cong, Yingzi
葡萄糖是人体的关键能量来源，被认为是各种自身免疫性疾病的潜在危险因素。然而，中等剂量的葡萄糖在自身免疫性炎性疾病和CD 4 + T细胞应答的调节中的作用是有争议的。在这里，我们表明，虽然高浓度（20%w/v）的葡萄糖促进肠道炎症，但它在中等剂量（6%w/v）下抑制结肠炎，这增加了肠道调节性T（Treg）细胞的比例，但不影响效应CD 4 + T细胞。葡萄糖处理促进Treg细胞分化，但不影响Treg稳定性。喂食葡萄糖会改变肠道微生物群的组成，而这些微生物群不参与Treg细胞的葡萄糖诱导。葡萄糖促进芳烃受体（AhR）活化以诱导Treg极化。这些发现揭示了不同剂量的葡萄糖对肠道免疫反应的不同影响。中等剂量的葡萄糖抑制肠道炎症葡萄糖促进Treg分化但不促进Treg稳定性微生物群不参与Treg细胞的葡萄糖诱导AhR介导Treg细胞的葡萄糖诱导生物科学;免疫学;免疫系统的组成部分;细胞生物学
Glucose, the critical energy source in the human body, is considered a potential risk factor in various autoimmune diseases when consumed in high amounts. However, the roles of glucose at moderate doses in the regulation of autoimmune inflammatory diseases and CD4+ T cell responses are controversial. Here, we show that while glucose at a high concentration (20% w/v) promotes intestinal inflammation, it suppresses colitis at a moderate dose (6% w/v), which increases the proportion of intestinal regulatory T (Treg) cells but does not affect effector CD4+ T cells. Glucose treatment promotes Treg cell differentiation but it does not affect Treg stability. Feeding glucose alters gut microbiota compositions, which are not involved in the glucose induction of Treg cells. Glucose promotes aryl hydrocarbon receptor (AhR) activation to induce Treg polarization. These findings reveal the different effects of glucose at different doses on the intestinal immune response. A moderate dose of glucose suppresses intestinal inflammation Glucose promotes Treg differentiation but not Treg stability Microbiota are not involved in the glucose induction of Treg cells AhR mediates the glucose induction of Treg cells Biological sciences; Immunology; Components of the immune system; Cell biology
登录
查看更多内容
影响因子：
14.9
作者：
Klindworth A;Pruesse E;Schweer T;Peplies J;Quast C;Horn M;Glöckner FO
通讯作者：
Glöckner FO
影响因子：
5.5
作者：
Manzel, Arndt;Muller, Dominik N.;Hafler, David A.;Erdman, Susan E.;Linker, Ralf A.;Kleinewietfeld, Markus
通讯作者：
Kleinewietfeld, Markus
影响因子：
17.1
作者：
Khan, Shahanshah;Waliullah, Sumyya;Zaki, Hasan
通讯作者：
Zaki, Hasan
影响因子：
30.5
作者：
De Rosa V;Galgani M;Porcellini A;Colamatteo A;Santopaolo M;Zuchegna C;Romano A;De Simone S;Procaccini C;La Rocca C;Carrieri PB;Maniscalco GT;Salvetti M;Buscarinu MC;Franzese A;Mozzillo E;La Cava A;Matarese G
通讯作者：
Matarese G
影响因子：
20.8
作者：
de Kivit, Sander;Mensink, Mark;Borst, Jannie
通讯作者：
Borst, Jannie