Tumor microenvironment and immune-related therapies of head and neck squamous cell carcinoma.
Tumor microenvironment and immune-related therapies of head and neck squamous cell carcinoma.
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头颈鳞癌的肿瘤微环境与免疫相关治疗
DOI：
10.1016/j.omto.2021.01.011
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发表时间：
2021-03-26
期刊：
影响因子：
--
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Qin Y;Zheng X;Gao W;Wang B;Wu Y
头颈部鳞状细胞癌是一种常见的恶性肿瘤，主要表现为口咽癌、口腔癌、喉咽癌、下咽癌和喉癌。据报道，这些高度侵袭性的恶性肿瘤每年影响全球830,000多名患者。目前，HNSCC的治疗方法主要有手术、放疗、化疗、免疫治疗以及综合治疗。然而，HNSCC的总体5年生存率一直保持在50%，在过去的10年里没有明显的改善。以往的研究表明，肿瘤微环境(TME)在HNSCC患者的复发、转移和耐药中起着至关重要的作用。本文就抗肿瘤免疫细胞、促肿瘤免疫细胞以及细胞外成分在HNSCC TME中的作用作一综述。我们还讨论了经典的HNSCC免疫治疗，并重点介绍了使用CTLA-4抑制剂和程序性细胞死亡1(PD-1)/程序性细胞死亡配体1(PD-L1)相关联合治疗的临床试验的例子。我们还概述了TME中一些已知的调节免疫抑制细胞的分子。此外，还讨论了放射治疗对TME、免疫细胞和免疫反应的作用和潜在机制。肿瘤微环境(TME)在肿瘤的复发、转移和耐药中起着关键作用。Wu及其同事概述了头颈部鳞状细胞癌(HNSCC)的TME和免疫治疗，并讨论了放射治疗对TME和HNSCC治疗的影响和前景。
Head and neck squamous cell carcinomas (HNSCCs) are a type of common malignant tumor, mainly manifesting as oropharyngeal, oral cavity, laryngopharyngeal, hypopharyngeal, and laryngeal cancers. These highly aggressive malignant tumors reportedly affect more than 830,000 patients worldwide every year. Currently, the main treatments for HNSCC include surgery, radiotherapy, chemotherapy, and immunotherapy, as well as combination therapy. However, the overall 5-year survival rate of HNSCC has remained 50%, and it has not significantly improved in the past 10 years. Previous studies have shown that the tumor microenvironment (TME) plays a crucial role in the recurrence, metastasis, and drug resistance of patients with HNSCC. In this review, we summarize the role of anti-tumor and pro-tumor immune cells, as well as extracellular components in the TME of HNSCC. We also discuss classical HNSCC immunotherapy and highlight examples of clinical trials using CTLA-4 inhibitors and programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1)-related combination therapies. We also outline some molecules in the TME known to regulate immunosuppressive cells. Furthermore, the role and underlying mechanism of radiation therapy on the TME, immune cells, and immune response are discussed. The tumor microenvironment (TME) plays a critical role in the recurrence, metastasis, and resistance of cancers. Wu and colleagues present an overview of the TME and immunotherapy in head and neck squamous cell carcinoma (HNSCC), together with a discussion of the effects and prospects of radiotherapy on the TME and HNSCC treatment.
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影响因子：
4.2
作者：
Acovic A;Simovic Markovic B;Gazdic M;Arsenijevic A;Jovicic N;Gajovic N;Jovanovic M;Zdravkovic N;Kanjevac T;Harrell CR;Fellabaum C;Dolicanin Z;Djonov V;Arsenijevic N;Lukic ML;Volarevic V
通讯作者：
Volarevic V
影响因子：
3.7
作者：
Dudás J;Fullár A;Bitsche M;Schartinger V;Kovalszky I;Sprinzl GM;Riechelmann H
通讯作者：
Riechelmann H
DOI：
10.1073/pnas.1800695115
发表时间：
2018-10-02
影响因子：
11.1
作者：
Feng, Shan;Cheng, Xi;Lu, Xin
通讯作者：
Lu, Xin
影响因子：
--
作者：
Bossi P;Resteghini C;Paielli N;Licitra L;Pilotti S;Perrone F
通讯作者：
Perrone F
影响因子：
3.9
作者：
Erdogan B;Webb DJ
通讯作者：
Webb DJ