Skeletal muscle ventricles as left atrial-aortic pumps: short-term studies.
Skeletal muscle ventricles as left atrial-aortic pumps: short-term studies.
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骨骼肌心室作为左心房-主动脉泵：短期研究。
DOI：
10.1016/0003-4975(92)91392-m
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Stephenson,LW
中科院分区：
文献类型：
--
作者：
Hooper,TL;Niinami,H;Hammond,RL;Lu,H;Ruggiero,R;Pochettino,A;Stephenson,LW
在5只狗中，从背阔肌构建骨骼肌心室（SMV），并将其放置在左半胸内。经过3周的血管延迟期，SMVs电预处理与2 Hz刺激6周。在第二次手术中，通过输入和输出主动脉根部同种移植物将SMV连接在左心房和胸主动脉之间，并刺激SMV以1：2舒张模式收缩。在平均左心房压力为12.4 ± 1.3 mm Hg和爆发刺激频率为33 Hz时，SMV每搏输出量最初为自体左心室的43%，达到相当于心输出量21%的流量（194 ± 38 vs 902 ± 85 mL/min）。在50 Hz刺激下，该数字上升至27%（246 ± 41 mL/min;p< 0.05）。在33 Hz时，骨骼肌心室功率输出（每搏作功与收缩率的乘积）为0.016 ± 0.003 W，在50 Hz时增加至0.024 ± 0.004 W（p< 0.05），分别相当于左心室功率输出（0.11 ± 0.012 W）的14%和22%。在连续泵送4小时后，四个SMV仍然产生超过初始值70%的流量和超过初始功率输出60%的流量。这项研究表明，SMV可以在生理左心房前负荷的体循环中发挥作用。
In 5 dogs, skeletal muscle ventricles (SMVs) were constructed from the latissimus dorsi muscle and placed in the left hemithorax. After a 3-week vascular delay period, SMVs were electrically preconditioned with 2-Hz stimulation for 6 weeks. At a second operation, SMVs were connected between the left atrium and thoracic aorta by afferent and efferent aortic root homografts, and stimulated to contract in a 1:2 diastolic mode. At a mean left atrial pressure of 12.4 ± 1.3 mm Hg and a burst stimulation frequency of 33 Hz, SMV stroke volume was initially 43% of that of the native left ventricle, achieving a flow equivalent to 21% of cardiac output (194 ± 38 versus 902 ± 85 mL/min). At 50-Hz stimulation, this figure rose to 27% (246 ± 41 mL/min;p< 0.05). Skeletal muscle ventricle power output (the product of stroke work and contraction rate) at 33 Hz was 0.016 ± 0.003 W, increasing to 0.024 ± 0.004 W at 50 Hz (p< 0.05), corresponding to 14% and 22%, respectively, of left ventricular power output (0.11 ± 0.012 W). After 4 hours of continuous pumping, four of the SMVs were still generating flows of more than 70% of starting values and more than 60% of initial power output. This study demonstrates that SMVs can function in the systemic circulation at physiologic left atrial preloads.
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